Long-acting articles for oral delivery and process

• US 4,039,653 A
• Filed: 07/21/1975
• Issued: 08/02/1977
• Est. Priority Date: 01/23/1974
• Status: Expired due to Term

• Current Assignee: Defoney Brenman Mayes & Baron
• Original Assignee: Defoney Brenman Mayes & Baron
• Inventors: Brenman, Henry S., DeFoney, George F., Mayes, Donald S.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US05/597,696
• Time in Patent Office: 743 Days
• Field of Search: 424/14, 424/16, 424/19-22, 424/48, 424/49, 128/260, 128/268, 252/316
• US Class Current: 424/435
• CPC Class Codes: A61K 2800/412 Microsized, i.e. having sizes between 0.1 and 100 microns
• CPC Class Codes: A61K 8/02 characterised by special physical form
• CPC Class Codes: A61K 8/0216 Solid or semisolid forms
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

Long-acting capsules or tablets containing materials for masking odors of the oral cavity or for introducing medications into the oral cavity or for introducing medications into the oral cavity in human beings and other animals and comprising suitable pharmaceutically acceptable odor masking or medicament substances in encapsulated form and present in a capsule, tablet or other article of such size and shape or of such material as to allow the article to reside for prolonged periods of time of at least one hour in adjacent contact with the oral mucosa.

Claims

1. A tablet for releasing a relatively uniform quantity of a medication or odor-masking material into the oral cavity of a human being or other animal over a prolonged period of time, said tablet comprising:

a. An elongated body;

b. Said body having at least one face having a concave curvature and adapted to fit comfortably along the upper surface of the gums at the side of the mouth;

c. Said tablet having a surface layer encompassing said tablet comprising principally pharmaceutically acceptable shellac having medicament or essential oil admixed therein to provide substantially immediate release of medicament or odor-masking material into the oral cavity; and

d. Said tablet having an inner core comprising principally a material selected from the group consisting of ethylcellulose, carboxymethylcellulose, methylcellulose and hydroxypropylcellulose having medicament or essential oil admixed therein for providing substantially more prolonged release of medicament or odor-masking material into the oral cavity.