Immunoassay for pharmacologically active phenethylamines

• US 4,041,076 A
• Filed: 03/09/1976
• Issued: 08/09/1977
• Est. Priority Date: 10/23/1974
• Status: Expired due to Term

• Current Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Original Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Inventors: Pecherer, Benjamin, Christenson, James Gordon, Avenia, Richard William
• Primary Examiner(s): Demers, Arthur P.
• Application Number:
  US05/665,205
• Time in Patent Office: 518 Days
• Field of Search: 260/559 A
• US Class Current: 564/114
• CPC Class Codes: C07D 207/404 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
• CPC Class Codes: G01N 33/9406 Neurotransmitters
• CPC Class Codes: Y10S 436/804 Radioisotope, e.g. radioimmunoassay
• CPC Class Codes: Y10S 530/807 Hapten conjugated with peptide or protein

Abstract

New hapten compositions useful in preparing antigens which may be employed in eliciting antibodies useful in an improved radioimmunoassay for pharmacologically active phenethylamines are disclosed. Particular phenethylamins which are preferably detected by the present radioimmunoassay include the catecholamines such as norepinephrine, dopamine and epinephrine, and the amphetamines.

Claims

1. N-[2-(4-hydroxyphenyl)ethyl]-2-[4-(2-aminopropyl)-phenoxy] acetamide.

2. N-[2-(4-hydroxyphenyl)ethyl]-2-[4-(2-aminopropyl)-phenoxy]acetamide-.sup.125 I.