1-Dimethylamino-2,4-diphenyl-1-butene-3,4-dione
First Claim
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1. A compound of the formula ##STR12## wherein R2 is phenyl, lower-alkoxyphenyl, di-lower-alkoxyphenyl, R3 is phenyl, naphthyl or nitrophenyl, and R4 and R5 taken independently are each lower alkyl.
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Abstract
Compounds of the formula ##STR1## wherein R1 is lower alkyl or phenyl lower alkyl; R2 is phenyl or substituted phenyl; and R3 is substituted or unsubstituted phenyl, naphthyl or indolyl;
Are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
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Citations
2 Claims
- 1. A compound of the formula ##STR12## wherein R2 is phenyl, lower-alkoxyphenyl, di-lower-alkoxyphenyl, R3 is phenyl, naphthyl or nitrophenyl, and R4 and R5 taken independently are each lower alkyl.
Specification
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Current AssigneeHoffmann-La Roche Incorporated (Roche Holding AG)
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Original AssigneeHoffmann-La Roche Incorporated (Roche Holding AG)
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InventorsWeigele, Manfred, Leimgruber, Willy, Grunberg, Emanuel, Cleeland, Roy Jr.
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Primary Examiner(s)Hines, Robert V.
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Application NumberUS05/668,179Time in Patent Office530 DaysField of Search260/570.5 C, 260/570.5 RUS Class Current564/342CPC Class CodesC07C 45/58 in three-membered ringsC07C 49/215 polycyclicC07D 307/60 Two oxygen atoms, e.g. succ...G01N 33/533 with fluorescent labelY10S 436/80 Fluorescent dyes, e.g. rhod...
