Apparatus for the inhalation of medicinal agents

• US 4,046,146 A
• Filed: 08/21/1975
• Issued: 09/06/1977
• Est. Priority Date: 08/22/1974
• Status: Expired due to Term

• Current Assignee: Schering Ag (Merck & Co., Inc.)
• Original Assignee: Schering Ag (Merck & Co., Inc.)
• Inventors: Kolberg, Reiner, Gunzel, Peter, Porep, Hans-Jurgen, Rosskamp, Gunter
• Primary Examiner(s): Michell, Robert W.
• Assistant Examiner(s): Recla, Henry J.
• Application Number:
  US05/606,737
• Time in Patent Office: 747 Days
• Field of Search: 128/266, 128/206-211, 222/193, 222/370
• US Class Current: 128/203.15
• CPC Class Codes: A61M 11/001 Particle size control
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0033 Details of the piercing or cutting means
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/0233 Conductive materials, e.g. antistatic coatings for spark prevention

Abstract

Apparatus for the inhalation of medicinal agent is disclosed which comprises forming an aerosol, containing the medicinal agent, within a venturi tube-shaped interior configuration. The apparatus comprises a housing for receiving incoming air and combining the same with a medicinal agent passed from a container supported on the housing. The housing has a converging air inlet chamber in communication with an adjacent constriction. The constriction, in turn, communicates with an aerosol delivery section via a diverging diffuser chamber. The diffuser chamber may be part of the housing and the delivery section, which section provides for oral or nasal application may be attached thereto. In the alternative, the diffuser chamber and aerosol delivery section may comprise a single section integrally formed with the housing. The diffuser chamber, constriction and air inlet chamber cooperate to define the venturi tube-shaped configuration. Medicinal agent from the container enters the housing interior proximate the constriction, thoroughly combines with incoming air to form an aerosol, and exhausts through the aerosol delivery section.

Claims

1. Apparatus for the inhalation of medicinal agents in pulverulent form, comprising a housing having a venturi tube-shaped interior configuration including a diffuser zone and provided with an aerosol exhaust section;

said housing including a dispensing opening having a delivery end which terminates upstream of the diffuser zone of the venturi-like housing, a container for the medicinal agent, means mounting said container on said housing for dispensing of the medicinal agent to said dispensing opening, and a collecting plate adjacent the delivery end of said dispensing opening and disposed longitudinally and transversely in close proximity to the venturi tube-shaped interior configuration of the housing.

2. Apparatus according to claim 1, wherein said container for the medicinal agent is provided with a dose dispensing device and is attached to the housing so that the passage from the dose dispensing device terminates within the housing upstream of the diffuser zone.

3. Apparatus according to claim 2, wherein said housing has an air inlet chamber with an air inlet opening at its upstream end, said chamber in communication at its downstream end with a tubular constriction;

said constriction being, in turn, in communication with said aerosol exhaust section.

4. Apparatus according to claim 3, wherein said air inlet chamber is a funnel-shaped member having an open upstream end from which said chamber converges inwardly.

5. Apparatus according to claim 4, wherein said container for the medicinal agent is disposed between said air inlet chamber and said constriction, said container having a tubular shaped.

6. The apparatus claim 5, wherein the interior of said container includes means for retaining medicinal agent therein.

7. Apparatus according to claim 4, wherein said container includes a dose dispensing device and a container holder fixedly joined to said housing.

8. Apparatus according to claim 7, wherein said container for the medicinal agent is provided with 2-24 dose dispensing chambers, said container being movable mounted on said container holder.

9. Apparatus according to claim 7, wherein a dose dispensing plate is movably mounted between said container holder and said container for the medicinal agent, said dose dispensing plate having 1-20 dose dispensing chambers.

10. Apparatus according to claim 1, wherein said aerosol exhaust section has a transversely elongate opening, said section initially diverging outwardly and then coverging.

11. Apparatus according to claim 1 wherein the dose dispensing opening is selectively opened and closed by movable means adjacent the upper end thereof.

12. Apparatus according to claim 11, wherein the interior housing configuration provides an air inlet opening at its upstream end and a downstream aerosol exhaust section communicating with the inlet opening through a tubular constriction transversely of which the collecting plate is mounted with its delivery end at the upstream end of the aerosol exhaust section.

13. Apparatus according to claim 12 wherein the collecting plate is substantially triangular with the longitudinal edges disposed along the adjacent surfaces of the air inlet opening.

14. Apparatus according to claim 13 wherein the collecting plate is longitudinally troughed.

15. Apparatus according to claim 14 wherein the delivery end of the dose dispensing opening is at the upstream side of the tubular constriction.