Ocular therapeutic system manufactured from copolymer
First Claim
1. An ocular therapeutic system for the controlled release of drug comprising a flexible body formed of a polymeric material permeable to the passage of drug by diffusion and containing a drug capable of diffusing through the material at a therapeutically effective rate, the body shaped, sized and adapted for comfortable insertion and retention in the cul-de-sac of the conjuctiva between the sclera of the eyeball and the lid to be held in place against the eyeball by the pressure of the lid, and wherein said polymeric material comprises an ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight, and a melt index of about 0.1 to 1000 grams per ten minutes.
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Abstract
Drug-delivery device for releasing a drug at a continuous and controlled rate for a prolonged period of time is comprised of a shaped body of polymeric material containing a pharmaceutically acceptable drug and permeable to passage of the drug by diffusion. The polymeric material is an ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight and a melt index of about 0.1 to 1000 grams per 10 minutes.
224 Citations
19 Claims
- 1. An ocular therapeutic system for the controlled release of drug comprising a flexible body formed of a polymeric material permeable to the passage of drug by diffusion and containing a drug capable of diffusing through the material at a therapeutically effective rate, the body shaped, sized and adapted for comfortable insertion and retention in the cul-de-sac of the conjuctiva between the sclera of the eyeball and the lid to be held in place against the eyeball by the pressure of the lid, and wherein said polymeric material comprises an ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight, and a melt index of about 0.1 to 1000 grams per ten minutes.
- 4. An ocular therapeutic system for the controlled release of drug comprising a flexible body formed of a polymeric material permeable to the passage of drug by diffusion and surrounding a drug capable of diffusing through the material at a therapeutically effective rate, the body shaped, sized and adapted for comfortable insertion and retention in the cul-de-sac of the conjunctiva between the sclera of the eyeball and the lid, to be held in place against the eyeball by the pressure of the lid, and wherein said polymeric material comprises an ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight, and a melt index of about 0.1 to 1000 grams per ten minutes.
- 8. An ocular therapeutic system for the controlled and continuous administration of drug to the eye of a warm blooded animal comprising a body formed of a polymeric material permeable to the passage of drug by diffusion and surrounding a drug capable of diffusing through the material at a therapeutically effective rate, the body shaped, adapted and sized with a length of 4 to 20 mm, a width of 0.1 to 12 mm and a thickness of 0.1 to 4 mm for insertion and retention in the eye, and wherein the material comprises an ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight and melt index of about 0.1 to 1000 grams per ten minutes, with the copolymer when the system is in the eye administering drug to the eye at a controlled rate over a prolonged period of time.
- 12. An ocular therapeutic system for the controlled administration of drug to the eye comprising a body formed of a drug release rate controlling ethylene-vinyl acetate copolymer permeable to the passage of drug by diffusion and containing a dosage amount of a drug capable of diffusing through the copolymer, said body shaped, adapted and sized for comfortable insertion and placement in the eye, and wherein the body when in the eye administers a therapeutically effective amount of drug by the drug dissolving in and passing through the copolymer at a controlled rate over a prolonged period of time.
- 16. An ocular therapeutic system for administering drug to the eye comprising a body shaped and sized for comfortable insertion and retention in the eye, the body formed of a drug release rate controlling ethylene-vinyl acetate copolymer having a vinyl acetate content of 4 to 80% by weight, permeable to the passage of drug by diffusion and surrounding a drug capable of diffusing therethrough, and wherein said body when in the eye administers a therapeutically effective amount of drug by passage through the copolymer at a controlled rate over a prolonged period of time.
Specification