Process for pheresis procedure and disposable pheresis bowl therefor
First Claim
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1. A unitary plasmapheresis centrifuge rotor, comprising, in combination:
- a. a red cell reservoir in the shape of a centrifuge bowl, said reservoir having a bottom wall which defines a drainage angle of at least 5° and
having a whole blood inlet and a plasma outlet;
b. a plasma reservoir in axial alignment with said red cell reservoir;
c. plasma duct means providing fluid communication between the plasma outlet of said red cell reservoir and said plasma reservoir;
d. air vent means communicating with said plasma reservoir; and
,e. means for engaging a centrifuge drive system whereby said centrifuge rotor can be spun to separate whole blood entering said red cell reservoir into a plasma component and a red cell component.
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Abstract
A pheresis process and apparatus for carrying it out. Blood from a donor is transferred to a pheresis bowl formed to have a red cell reservoir and a plasma reservoir in fluid communication through plasma ducts. The pheresis bowl is adapted for centrifuging to separate the red cells and plasma. This separation is accomplished simultaneously with the withdrawal of blood from the donor. At the end of the withdrawal the red cells are returned to the donor. The connection with the donor is thus continuously maintained during the entire procedure. The process is safe, fast and economical.
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Citations
31 Claims
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1. A unitary plasmapheresis centrifuge rotor, comprising, in combination:
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a. a red cell reservoir in the shape of a centrifuge bowl, said reservoir having a bottom wall which defines a drainage angle of at least 5° and
having a whole blood inlet and a plasma outlet;b. a plasma reservoir in axial alignment with said red cell reservoir; c. plasma duct means providing fluid communication between the plasma outlet of said red cell reservoir and said plasma reservoir; d. air vent means communicating with said plasma reservoir; and
,e. means for engaging a centrifuge drive system whereby said centrifuge rotor can be spun to separate whole blood entering said red cell reservoir into a plasma component and a red cell component. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 29, 30, 31)
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28. A unitary plasmapheresis centrifuge rotor comprising, in combination:
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a. a lower red cell reservoir in the shape of a centrifuge bowl, said reservoir having a bottom wall which defines a drainage angle of at least 5° and
has a central opening suitable for engagement with tubing defining a fluid channel, said red cell reservoir having an upper centrally positioned reentrant weir;b. an upper plasma reservoir in axial alignment with said lower red cell reservoir said plasma reservoir having means to divide it into two chambers in fluid communication; c. oppositely disposed ducts providing fluid communication between said red cell reservoir and said plasma reservoir, each of said ducts including radial duct sections extending outwardly and at an upwardly directed slope from said reentrant weir of said red cell reservoir; and d. vent means providing fluid communication between the ambient atmosphere and said red cell and plasma reservoirs and between said reservoirs.
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Specification