Analytical test strip apparatus
First Claim
1. An analytical test strip apparatus comprising:
- at least one substantially flat strip having a front layer and a back layer, said front and back layers defining a channel therebetween through which a sample of liquid may pass, said strip also including a sample input port and a terminating end, at least one of said layers being relatively pliable;
a plurality of process station means linearly located in said channel; and
,a thin layer of an inert liquid medium located in said channel, said liquid medium adhering said two layers to each other and being strong enough to prevent the forward movement of said sample in said channel solely under the influence of gravity but weak enough to allow said sample to linearly pass in a predetermined sequence through said plurality of station means in said channel under the influence of an exterior propelling means, said liquid medium so filling said channel as to constitute the medium through which the sample is propelled, the dimensions of said liquid medium being sufficiently broad so as to substantially exclude contaminating air from said station means.
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Abstract
Analytical test strip apparatus for chemical, physical and biological experiments on small samples of fluids or fluid-like materials, consists of a thin, flat, hollow, pliable strip the interior including a channel completely filled with a thin layer of an inert liquid, preferably of a grease like consistency, into which liquid is introduced a small amount of the fluid to be tested, to form a movable "blister". The blister is propelled through the inert liquid, which confines it at all times front and rear, by applied external pressure. A plurality of chemical, physical, biological or detection stations are typically located in said channel. A physical station might consist of a filter membrane; a chemical station of a small pocket of chemical reagent; a detecting station of a material sensitive to pH. The stations are confined by the inert liquid filling the interior channel of the strip. In addition to forming the front and rear walls of the movable blister, the inert liquid also prevents migration of reagent located in a station, excludes air and other matters and prevents escape of noxious material being analyzed. In operation, a small portion of fluid is introduced into the strip top and the top is pinched to form a bubble or blister therein. The pinch line is drawn down the strip length forcing the blister ahead of it. As the blister proceeds down the tube, it is subjected to chemical, physical, biological and detecting operations as it passes through the different stations. One side of the tube being preferably transparent, results of the operations may be visible to the eye.
224 Citations
19 Claims
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1. An analytical test strip apparatus comprising:
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at least one substantially flat strip having a front layer and a back layer, said front and back layers defining a channel therebetween through which a sample of liquid may pass, said strip also including a sample input port and a terminating end, at least one of said layers being relatively pliable; a plurality of process station means linearly located in said channel; and
,a thin layer of an inert liquid medium located in said channel, said liquid medium adhering said two layers to each other and being strong enough to prevent the forward movement of said sample in said channel solely under the influence of gravity but weak enough to allow said sample to linearly pass in a predetermined sequence through said plurality of station means in said channel under the influence of an exterior propelling means, said liquid medium so filling said channel as to constitute the medium through which the sample is propelled, the dimensions of said liquid medium being sufficiently broad so as to substantially exclude contaminating air from said station means. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 13, 14, 15, 16, 17, 18, 19)
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2. An analytical test strip apparatus comprising:
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a substantially flat strip having a front layer and a back layer, said front and back layers defining a channel therebetween through which a fluid may pass, said strip also including a fluid input port and a terminating end, at least one of said layers being relatively pliable; a plurality of process stations linearly located within said channel and including at least one temperature detection station; and
,a thin layer of an inert liquid medium located in said channel, said liquid medium adhering said front and back layers to each other and being strong enough to prevent the forward movement of said fluid in said channel solely under the influence of gravity but weak enough to allow said fluid to pass linearly through said channel under the influence of an exterior propelling means, said liquid medium so filling said channel as to constitute the medium through which the fluid is propelled.
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3. An analytical test strip apparatus comprising:
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at least one substantially flat strip having a front layer and a back layer, said front and back layers defining a channel therebetween through which a sample of fluid may pass, said strip also including a sample input port and a terminating end, least one of said layers being partially translucent and at least one of said layers being relatively pliable; a plurality of process station means linearly located in said channel; a propelling means for linearly propelling said sample through said channel; and
,a thin layer of an inert liquid medium located in said channel, said liquid medium adhering said two layers to each other and being strong enough to prevent the forward movement of said sample in said channel solely under the influence of gravity, but weak enough to allow said sample to pass through said channel under the influence of said propelling means, said liquid medium filling said channel so as to constitute the medium through which the sample is propelled and substantially excluding contaminating air from said station means, wherein said sample is introduced into said top sample input port and then linearly moved toward said terminating end through said liquid medium as an air-free mass by said propelling means thereby passing said sample in a predetermined sequence through said plurality of station means located in said channel.
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12. The invention of claim 12 wherein said strip includes at least one detection station comprising a clear plastic window through which optical instruments can analyze the properties of said sample.
Specification