Apparatus for the precipitation of human blood plasma components

• US 4,066,549 A
• Filed: 09/18/1975
• Issued: 01/03/1978
• Est. Priority Date: 09/18/1974
• Status: Expired due to Term

• Current Assignee: Blutspendedientst Der Landesverbande Des Deutshen Roten Kreuzes Niedersachen Oldenburg and Bremen GmbH
• Original Assignee: Blutspendedientst Der Landesverbande Des Deutshen Roten Kreuzes Niedersachen Oldenburg and Bremen GmbH
• Inventors: Oeser, Henning, Ahrens, Ulrich
• Primary Examiner(s): Richman, Barry S.
• Application Number:
  US05/614,419
• Time in Patent Office: 838 Days
• Field of Search: 23/258.5 R, 260/112 B, 210/201, 210/206, 210/254, 210/257 R, 210/177, 210/179, 210/181, 210/45, 210/DIG. 23
• US Class Current: 210/177
• CPC Class Codes: A61K 35/16 Blood plasma; Blood serum umbilical cord blood A61K35/51
• CPC Class Codes: Y10S 530/83 Plasma; serum

Abstract

A process and apparatus for the precipitation of human blood plasma components characterized in that the initial blood plasma and the precipitating agent are continuously introduced into a precipitation container in an adjusted relationship but separated with simultaneous control of the required pH values. The suspension of the individual precipitants is conveyed across a delay station and then separated. The delay station includes a flow passageway connecting the precipitation container to a separating means, with the flow passageway being so constructed as to permit substantially laminar flow of fluid therethrough. Means are also present in the flow passageway for changing the residence time of fluid therein by permitting selective variation of the length of the flow passageway.

Claims

1. An apparatus for the continuous precipitation of human blood plasma components comprising:

individual supply containers for blood plasma, a precipitation agent and a buffer solution,

a precipitation vessel,

means for conveying the blood plasma and the precipitation agent from the respective supply containers to said precipitation vessel and including means for combining the blood plasma and precipitating agent immediately upstream of said precipitation vessel,

means for conveying the buffer solution from its respective supply container to said precipitation vessel,

means for cooling said precipitation vessel and the contents thereof,

means for causing turbulence in said precipitation vessel,

a flow passageway connecting said precipitation vessel and centrifuge means, said flow passageway being so constructed as to permit substantially laminar flow of fluid therethrough,

means for selectively changing the residence time of fluid in said flow passageway by varying the length of said flow passageway through which fluid is caused to flow, and

means for removing the centrifugate from said centrifuge means.

2. An apparatus as in claim 1 and wherein:

said flow passageway is arranged in a sinusoidal path and includes valve means for selecting that portion of the flow passageway through which fluid may flow.

3. An apparatus as in claim 2 and including:

an intermediate container provided near the end of said flow passageway and means connecting said intermediate container and said centrifuge means.

4. An apparatus as in claim 2 and including:

a centrifugate receiving container connected to said centrifuge means,

a second said apparatus for precipitation of human blood plasma components connected in series, said centrifugate receiving container of the first apparatus comprising the blood plasma supply container for the second apparatus.