Positive and negative ion recording system for mass spectrometer

• US 4,066,894 A
• Filed: 01/20/1976
• Issued: 01/03/1978
• Est. Priority Date: 01/20/1976
• Status: Expired due to Term

• Current Assignee: University of Virginia
• Original Assignee: University of Virginia
• Inventors: Hunt, Donald F., Stafford, George C. Jr.
• Primary Examiner(s): Smith, Alfred E.
• Assistant Examiner(s): Anderson, B. C.
• Application Number:
  US05/650,783
• Time in Patent Office: 714 Days
• Field of Search: 250/423, 250/424, 250/292, 250/291, 250/293, 250/285, 250/282
• US Class Current: 250/292
• CPC Class Codes: H01J 49/0095 Particular arrangements for generating, introducing or analyzing both positive and negative analyte ions ion/ion reactions H01J49/0072
• CPC Class Codes: H01J 49/025 Detectors specially adapted to particle spectrometers data acquisition H01J49/0036; detectors per se G01T, e.g. G01T1/28, G01T1/29
• CPC Class Codes: H01J 49/4215 Quadrupole mass filters H01J49/4225 takes precedence

Abstract

A method and an apparatus are disclosed for adapting a conventional quadrupole mass spectrometer to substantially simultaneously produce and record both positive and negative ions. The apparatus includes a control circuit for rapidly switching the repeller, source and lens electrodes of a quadrupole mass spectrometer between positive and negative potentials. This switching of the potentials, along with the selection of appropriately favorable ionization conditions, permits the generation of suitable streams of positive and negative ions. A dual electron multiplier detector is used for separately sensing the positive and negative ions transmitted through the quadrupole mass spectrometer. The disclosed method and apparatus are particularly suitable for obtaining accurate mass measurements using a quadrupole mass spectrometer.

Claims

1. A method of generating and monitoring positive and negative ions substantially simultaneously using a quadrupole mass spectrometer having an ion generator with repeller, source and lens electrodes, and a quadrupole filter, comprising the steps of:

operating the mass spectrometer under conditions favoring the generation of positive and negative ions;

alternately transmitting the positive ions and the negative ions at a frequency in excess of 1 kHz, through the quadrupole filter; and

separately extracting the alternately transmitted positive ions and negative ions at the output of the quadrupole filter.

2. The method recited in claim 1 including the steps of:

producing electrical signals representative of the positive ions and the negative ions extracted in the step of extracting; and

processing the electrical signals.

3. The method recited in claim 1, wherein the step of operating includes the steps of:

using a reagent gas such as isobutane at a pressure of approximately one torr as a reagent gas; and

using perfluorokerosene as an internal standard material.

4. The method recited in claim 1 wherein the step of transmitting includes the step of:

switching the relative potential applied between source and quadrupole filter electrodes.

5. The method recited in claim 1 wherein the transmitting step includes:

alternately transmitting the positive ions and the negative ions at a frequency of 10 kHz. through the quadrupole filter.

6. An apparatus for enabling a quadrupole mass spectrometer, having an ion generator with repeller, source and lens electrodes, and a quadrupole filter, to effectively simultaneously generate and monitor both positive and negative ions, comprising:

means for alternately transmitting positive ions and negative ions at a frequency in excess of 1 kHz. through the quadrupole filter; and

dual extraction means for separately extracting the alternately transmitted positive ions and negative ions at the output of the quadrupole filter.

7. The apparatus recited in claim 6 wherein the transmitting means includes:

a plurality of independently adjustable voltage sources;

electronic switching circuit means coupled to the voltage sources for selectively connecting the voltage sources with said quadrupole mass spectrometer; and

timing circuit means coupled to the electronic switching circuit means for controlling the switching frequency thereof.

8. The apparatus recited in claim 7 wherein the transmitting means includes:

mode selective switch means coupled to the timing and electronic switching circuit means for selectively disabling the timing circuit means and for selectively establishing a fixed condition of the switching circuit means.

9. The apparatus recited in claim 7 wherein:

the plurality of voltage sources includes at least four independently variable voltage dividers for independently setting desired positive and negative voltage levels.

10. The apparatus recited in claim 8 wherein the transmitting means includes:

output power amplifiers adapted to be coupled between the switching circuit means and the repeller, source and lens electrodes.

11. The apparatus recited in claim 6 wherein the dual extraction means includes:

a pair of electron multiplier tubes adapted to be coupled to the output of the quadrupole filter;

negative biasing means coupled to one of the tubes for attracting positive ions; and

positive biasing means coupled to the other tube for attracting negative ions.

12. The apparatus recited in claim 11 including:

cross-talk reducing means coupled to the dual extraction means for reducing cross-talk between the electron multiplier tubes.

13. The apparatus recited in claim 12 wherein the cross-talk reducing means includes:

a conductive plate including a pair of apertures, the apertures positioned to permit ions to pass through the plate and impinge upon the electron multiplier tubes; and

an upstanding separating fin secured to the plate midway between the apertures.