Amino derivatives of 1,2,3,4-tetrahydro-2-oxopyrido[2,2-b]-pyrazine carboxylic acids and esters

• US 4,077,955 A
• Filed: 02/17/1977
• Issued: 03/07/1978
• Est. Priority Date: 02/17/1977
• Status: Expired due to Term

• Current Assignee: E R Squibb & Sons Incorporated
• Original Assignee: E R Squibb & Sons Incorporated
• Inventors: Denzel, Theodor, Hoehn, Hans
• Primary Examiner(s): Daus, Donald G.
• Assistant Examiner(s): Turnipseed, James H.
• Application Number:
  US05/769,633
• Time in Patent Office: 383 Days
• Field of Search: 260/250 BC
• US Class Current: 544/350
• CPC Class Codes: C07D 213/80 in position 3
• CPC Class Codes: C07D 471/04 Ortho-condensed systems

Abstract

Amino derivatives of 1,2,3,4-tetrahydro-2-oxopyrido[2,3-b]-pyrazine carboxylic acid and esters and their acid addition salts which have the general formula ##STR1## are useful as anti-inflammatory agents and central nervous system depressants.

Claims

1. A compound of the formula ##STR29## wherein R and R² each is hydrogen or lower alkyl;

R¹ is hydrogen, lower alkyl, di(lower alkylamino)lower alkylene, and pharmacuetically acceptable acid addition salts thereof.

2. A compound as in claim 1 wherein R is hydrogen or lower alkyl of 1 to 4 carbon atoms;

R¹ is hydrogen, lower alkyl of 1 to 4 carbon atoms, or di(lower alkylamino)lower alkylene; and

R² is lower alkyl.

3. A compound as in claim 1 wherein R is ethyl;

R² is methyl; and

R¹ has the same meaning as in claim 2.

4. A compound as in claim 1 wherein R, R¹ and R² each is lower alkyl.

5. A compound as in claim 1 wherein R is ethyl, R² is methyl and R¹ is butyl.

6. A compound as in claim 1 wherein R is ethyl, R² is methyl, and R¹ is methylpropyl.

7. A compound as in claim 1 wherein R and R² each is lower alkyl and R¹ is di(lower alkylamino)lower alkylene.

8. A compound as in claim 1 wherein R is ethyl, R² is methyl and R¹ is dimethylaminopropyl.

9. A compound as in claim 1 wherein R is ethyl, R² is methyl and R¹ is dimethylaminoethyl.