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Permanent suspension pharmaceutical dosage forms

  • US 4,080,445 A
  • Filed: 09/24/1976
  • Issued: 03/21/1978
  • Est. Priority Date: 01/02/1975
  • Status: Expired due to Term
First Claim
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1. An anhydrous pharmaceutical vehicle suitable for oral administration of a water sensitive drug permanently suspended therein, wherein said water sensitive drug is selected from the group consisting of tetracycline, chlorotetracycline and oxytetracycline, said vehicle consisting essentially of:

  • a. about 5 to 60 percent by weight of a sugar suspending agent selected from the class consisting of sucrose, lactose, fructose, glucose, mannitol, and sorbitol;

    b. about 0.1 to about 5 percent by weight of a pharmaceutically acceptable silica thickening agent having a particle size of about 2 to about 4 microns, an alkaline pH (5 percent slurry in water) no higher than 8, and an oleophilicity of about 1;

    c. the remainder being a pharmaceutically acceptable vegetable oil comprising monoglyceride, diglyceride or triglyceride of a saturated fatty acid containing 14 to 22 carbon atoms or monoglyceride, diglyceride or triglyceride of an unsaturated fatty acid containing 14 to 22 carbon atoms.

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