Macromolecular adenine nucleotide derivatives
First Claim
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1. 4-(6-nicotinamide adenine dinucleotide)-3-hydroxybutyril polyethyleneimine.
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Abstract
A macromolecular adenine derivative containing at least one unity having the general formula: ##STR1## wherein, n is 1, 2, 3 or 4; the radical: ##STR2## is derived from an adenine derivative wherein the amino group in position 6 in the adenine nucleus is functional; and the nitrogen atom, N<, belongs to a macromolecular compound containing one or more primary or secondary amine groups, is prepared by condensing the functional adenine derivative with a polymer containing one or more primary or secondary amine groups in the presence of a carbodiimide. These compounds are useful in affinity chromatographies or as unspreading co-enzymes.
16 Citations
3 Claims
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1. 4-(6-nicotinamide adenine dinucleotide)-3-hydroxybutyril polyethyleneimine.
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2. 4-(6-nicotinamide adenine dinucleotide)-3-hydroxybutyril poly-L-lysine.
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3. 4-(6-nicotinamide adenine dinucleotide)-3-hydroxybutyril Sepharose 4B.
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Current AssigneeANIC SPA
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Original AssigneeSnamprogetti S.p.A.
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InventorsZappelli, Piergiorgio, Re, Luciano, Marconi, Walter
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Primary Examiner(s)Brown, Johnnie R.
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Application NumberUS05/586,354Time in Patent Office1,062 DaysField of Search260/211.5 R, 260/112.5 R, 536/27, 536/28, 536/29US Class Current530/322CPC Class CodesC08F 120/60 containing nitrogen in addi...C08F 126/02 by a single or double bond ...C08F 8/10 AcylationC08G 69/48 Polymers modified by chemic...C08G 73/0273 Polyamines containing heter...C08G 73/06 Polycondensates having nitr...C12Q 1/008 for determining co-enzymes ...Y10S 435/814 Enzyme separation or purifi...
