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Osmotic releasing device having a plurality of release rate patterns

  • US 4,093,708 A
  • Filed: 03/09/1977
  • Issued: 06/06/1978
  • Est. Priority Date: 12/23/1974
  • Status: Expired due to Term
First Claim
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1. A method for administering an ophthalmic drug to the tear fluid of the eye comprising,a. placing in the eye tear fluid an osmotic device comprising;

  • 1. a shaped wall formed of a semipermeable material that maintains its integrity during the dispensing period, is permeable to the passage of eye fluid and essentially impermeable to the passage of drug;

    2. the wall surrounding and forming a compartment containing an ophthalmic drug that exhibits an osmotic pressure gradient across the wall against the eye fluid;

    3. a layer formed of a material that bioerodes in the eye tear fluid on at least a part of the exterior surface of the semi-permeable wall;

    4. a passageway in the wall, said passageway communicating with the compartment and the exterior of the device for dispensing drug from the device;

    b. bioeroding the layer in the eye tear fluid at a controlled rate to regulate the amount of eye fluid available to the wall for imbibition, which fluid is imbibed through the wall into the compartment in a tendency towards osmotic equilibrium at a rate determind by the permeability of the wall and the osmotic pressure gradient across the wall continuously dissolving drug; and

    thereby,c. dispensing drug from the device to the eye tear fluid through the passageway at a controlled rate over a prolonged period of time.

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