Method and an arrangement for continuously measuring the partial pressure of a gas in a sample

• US 4,094,305 A
• Filed: 08/06/1976
• Issued: 06/13/1978
• Est. Priority Date: 04/23/1976
• Status: Expired due to Term

• Current Assignee: Manfred Kessler
• Original Assignee: Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften e.V. (Max-Planck-Gesellschaft zur Frderung der Wissenschaften e)
• Inventors: Kessler, Manfred
• Primary Examiner(s): Michell, Robert W.
• Assistant Examiner(s): Thaler, Michael H.
• Application Number:
  US05/712,248
• Time in Patent Office: 676 Days
• Field of Search: 128/2 E, 128/2 G, 128/2 L, 128/2.1 E, 204/195 B, 204/195 P
• US Class Current: 600/355
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1477 non-invasive

Abstract

A method and an arrangement for continuously measuring the partial pressure of a gas in a sample, particularly of oxygen dissolved in blood flowing through muscle tissue which is covered by a skin layer, comprises a support probe which is adapted to be positioned intermediate the skin layer and a portion of the sample so that the probe is fixedly held in position against the sample portion. A polarographic cell is mounted on the probe and has a gas-measuring part which is in firm engagement with the sample portion so as to generate a signal indicative of the amount of gas being diffused from the sample portion. The polarographic cell is interchangeably and detachably mounted on the probe so as to facilitate sterilization of the various parts of the arrangement. A plurality of gas-measuring electrodes are utilized in combination with an indicating arrangement to either measure the distribution of the oxygen gas being diffused over an area of the sample portion or to measure the average value of gas being diffused from the latter.

Claims

1. An arrangement for continously measuring the partial pressure of oxygen dissolved in blood flowing through muscle tissue which is covered by a skin layer, a combination comprising a support probe having first and second sides which are respectively adapted to engage the underside of the skin layer and the surface of the muscle tissue so that said probe is fixedly held in position against the muscle tissue;

and a polarographic cell mounted at said second side and having a gas-measuring part adapted to firmly engage said muscle tissue so as to generate a signal indicative of the amount of gas being diffused from said muscle tissue, said probe further including a tubular section connected to said first side thereof, said first side of said probe comprising tapered wall surface portions which diverge in direction from said tubular section towards said muscle tissue so that said tapered wall surface portions are adapted to be positioned in sealing engagement with the underside of said skin layer.

2. An arrangement as defined in claim 1;

and further comprising means for interchangeably and detachably mounting said cell on said probe, comprising a recess formed in said second side, and a flange part provided on said cell, said flange part being lodged in said recess.

3. An arrangement as defined in claim 1, wherein said gas-measuring part of said cell comprises an electrolyte, a reference electrode and a sensor electrode in electrolytic contact with said reference electrode;

and further comprising means for indicating the amount of gas diffused from said muscle tissue in dependence upon the value of said generated signal; and

further comprising conductive means for conveying said signal in direction away from said electrodes and towards said indicating means.

4. An arrangement as defined in claim 3, wherein said conductive means comprises conductors electrically connected between said electrodes and said indicating means;

and a tubular section having an internal elongated passage in which said conductors are received.

5. An arrangement as defined in claim 4, wherein said cell further comprises a detachable cover;

and further comprising means for relieving the stress of said conductors, comprising stress-relief members each mounted on said covers and having a support which supports a different part of a respective conductor.

6. An arrangement as defined in claim 1, wherein said probe at said second side has a generally disk-shaped configuration.

7. An arrangement as defined in claim 1, wherein said second side has a generally circular configuration which has a diameter which is at least 20 mm and at most 35 mm.

8. An arrangement as defined in claim 1, wherein said gas-measuring part of said cell comprises a plurality of rod-shaped sensor electrodes, each having a cross-sectional diameter of between 10 microns and 20 microns.

9. An arrangement as defined in claim 1;

and further comprising means for measuring the distribution of the gas being diffused over an area of said muscle tissue, said measuring means comprising a plurality of sensor electrodes arranged in said cell at spaced locations therein, each sensor electrode being operative to generate a signal component at a respective one of said locations; and

further comprising means for individually indicating a respective one of said signal components generated at each of said locations, said indicating means comprising a plurality of indicating devices each connected with a respective one of said sensor electrodes.

10. An arrangement as defined in claim 1;

and further comprising means for measuring the mean amount of gas bring diffused from said muscle tissue, said measuring means comprising a plurality of sensor electrodes arranged in said cell at spaced locations therein, each sensor electrode being operative to generate a signal component at a respective one of said locations; and

further comprising means for combining all of said signal components so as to obtain a mean value for the gas being diffused at each one of said locations; and

further comprising means for indicating said mean value.

11. A method of continuously polarographically measuring the partial pressure of gas in a sample, particularly of oxygen dissolved in blood flowing through muscle tissue which is covered by a skin layer, the method comprising the steps of incising the skin layer so as to form an incision;

inserting through the incision a probe on one side of which is mounted a polarographic cell, engaging the surface of the muscle with said one side of said probe and said polarographic cell mounted thereon, and engaging the underside of the skin layer with the other side of said probe; and

with the underside of said skin layer engaged by said other side of said probe, and with said one side of said probe and the polarographic cell mounted thereon both engaging said surface of the muscle tissue, using the polarographic cell to generate a signal indicative of the amount of gas being diffused from said surface of the muscle tissue.

12. The method as defined in claim 11;

and further comprising the step of measuring the distribution of the gas being diffused over an area of said surface, said measuring step including the step of using a plurality of gas-measuring sensor electrodes at spaced locations in said cell, each sensor electrode generating a signal component at a respective one of said locations, and the step of seperately indicating a respective one of said signal components generated at each of said locations.

13. The method as defined in claim 11;

and further comprising the step of measuring the mean amount of gas being diffused from said surface, said measuring step including the step of using a plurality of gas-measuring sensor electrodes at sapced locations in said cell, each sensor electrode generating a signal component at a respective one of said locations, and combining all of said signal components so as to obtain a mean value for the gas being diffused at each one of said locations, and indicating said mean value.