Dialysis system

• US 4,094,775 A
• Filed: 02/28/1977
• Issued: 06/13/1978
• Est. Priority Date: 02/28/1977
• Status: Expired due to Term

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Mueller, William A.
• Primary Examiner(s): Hart, Charles N.
• Assistant Examiner(s): Cross, E. Rollins
• Application Number:
  US05/772,434
• Time in Patent Office: 470 Days
• Field of Search: 210/22, 210/23, 210/321 B
• US Class Current: 210/646
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: B01D 61/28 Apparatus therefor
• CPC Class Codes: B01D 71/261 Polyethylene
• CPC Class Codes: B01D 71/78 Graft polymers

Abstract

The improved hemodialysis system utilizes a second polymeric membrane having dialyzate in contact with one surface and a urea decomposition solution in contact with the other surface. The membrane selectively passes urea from the dialyzate into the decomposition solution, while preventing passage of positively charged metal ions from the dialyzate into the solution and ammonium ions from the solution into the dialyzate.

Claims

1. A system for selectively removing urea from an aqueous liquid containing urea and positive metal cations comprising in combination:

a container divided into a first chamber and a second chamber by means of a continuous sheet of cationically charged polymeric membrane selectively permeable to urea and having low permeability to cations;

said first chamber including means for receiving said liquid; and

said second chamber receiving a solution containing a urea decomposition agent whereby said cations are repelled by said membrane and retained in said liquid and urea permeates through the membrane into the solution and is decomposed into bicarbonate and ammonium, the ammonium being retained in the solution in the second chamber.

2. A system according to claim 1 in which the membrane contains quaternary ammonium groups.

3. A system according to claim 2 in which the membrane is a vinyl pyridine grafted polyethylene.

4. A system according to claim 1 in which the membrane has a thickness from 1 to 15 mils.

5. A system according to claim 4 in which the membrane has an exchange capacity of 1 to 20 meq/gm.

6. A system according to claim 1 in which the first chamber is a hollow body having said membrane as one wall thereof and having an inlet and outlet for flowing said liquid past a first surface of the membrane.

7. A system according to claim 1 in which the urea decomposition agent is urease.

8. A system according to claim 7 in which the urease concentration of the solution is at least 25% by weight of the urea content of the liquid.

9. A system according to claim 7 in which the liquid is dialyzate containing urea and further including a blood dialysis membrane selectively permeable to urea having one surface in contact with said dialyzate and a second surface for contacting a flow of blood.

10. A method of selectively removing urea from an aqueous liquid containing urea and positive metal cations comprising the steps of:

placing the liquid in contact with a first surface of a cationically charged polymeric membrane selectively permeable to urea and having low permeability to cations;

placing an urea decomposition solution containing an urea decomposition agent in contact with a second surface of the membrane; and

selectively permeating urea from the liquid through the membrane into the solution thereby decomposing urea into ammonium cations and bicarbonate whereby the ammonium cations are retained in the decomposition solution and the metal cations are retained in the liquid.

11. A method according to claim 10 in which the membrane contains quaternary ammonium groups.

12. A method according to claim 11 in which the membrane has an exchange capacity of from 1 to 20 meq/gm.

13. A method according to claim 12 in which the membrane is a vinyl pyridine grafted polyethylene having a thickness from 1 to 15 mils.

14. A method according to claim 11 in which the agent is urease.

15. A method according to claim 14 in which the urease concentration of the decomposition solution is at least 25% of the concentration of urea in the urea containing liquid.

16. A method according to claim 14 in which the urea containing liquid is dialyzate from a blood dialysis unit.

17. A method according to claim 14 in which the urea containing liquid is blood.

18. An artificial kidney machine comprising in combination:

enclosure means having an inlet and an outlet, and having a wall surface formed of a cationically charged membrane defining a channel for flowing urea containing blood past one surface of the membrane;

urea removal means comprising walls defining a chamber, said chamber including a solution of urease having a concentration at least 25% by weight of the urea content of the blood; and

means for supplying the urea permeate from the second surface of the membrane to the urease solution.

19. A machine according to claim 18 in which the membrane forms a common wall portion of said channel and chamber.