Method and apparatus for extravascular treatment of blood
First Claim
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1. A method for the extracorporeal treatment of the blood of a patient afflicted with hyperlipemia and/or hypercholesteremia to effect a reduction of the β
- and pre-β
lipoproteins in said blood without substantially affecting the remaining constituents of the blood, which comprises;
(a) withdrawing a portion of blood from said patient,(b) contacting said blood portion with a water-insoluble gel of a sulfated polysaccharide coupled to an activated non-sulfated polysaccharide having its remaining sites blocked, in the presence of calcium cation in a concentration of 0.02 to 0.04M, thereby selectively binding a substantial portion of the beta and pre-beta lipoproteins with the calcium complex gel,(c) causing the thus treated blood portion to be filtered, thereby to separate the treated blood portion from the complex gel, whereby there is obtained the same blood portion wherein the initial amount of beta and pre-beta lipoproteins has been substantially reduced without affecting the remaining constituents of the blood, and(d) returning the thus filtered blood portion to the patient.
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Abstract
There is provided a method and apparatus for the excorporeal treatment of blood of hyperlipemic anc hypercholesteremic patients whereby a portion of blood is drawn from such patients and treated with a divalent metal complex of a sulphated polysaccacharide coupled to a non-sulphated polysaccharide gel having its remaining sites blocked whereby a substantial amount of the lipoproteins present in the blood are bound to the gel and then filtering the blood before returning same to the patient.
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Citations
14 Claims
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1. A method for the extracorporeal treatment of the blood of a patient afflicted with hyperlipemia and/or hypercholesteremia to effect a reduction of the β
- and pre-β
lipoproteins in said blood without substantially affecting the remaining constituents of the blood, which comprises;(a) withdrawing a portion of blood from said patient, (b) contacting said blood portion with a water-insoluble gel of a sulfated polysaccharide coupled to an activated non-sulfated polysaccharide having its remaining sites blocked, in the presence of calcium cation in a concentration of 0.02 to 0.04M, thereby selectively binding a substantial portion of the beta and pre-beta lipoproteins with the calcium complex gel, (c) causing the thus treated blood portion to be filtered, thereby to separate the treated blood portion from the complex gel, whereby there is obtained the same blood portion wherein the initial amount of beta and pre-beta lipoproteins has been substantially reduced without affecting the remaining constituents of the blood, and (d) returning the thus filtered blood portion to the patient. - View Dependent Claims (2, 3, 4)
- and pre-β
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5. In an apparatus for removing a substantial amount of β
- 0 and pre-β
lipoproteins from blood comprising recipient means for receiving therein blood to be treated;
means allowing the removal of treated blood from said recipient means; and
filter means disposed between said gel support and said means allowing treated blood removal, the improvement comprising a calcium metallic complex of sulfated polysaccharide coupled to an activated non-sulfated polysaccharide gel support wherein the remaining sites are blocked being contained in said recipient means whereby, when in the presence of said gel support, said blood is treated by the fixing of a substantial amount of β and
pre-β
lipoproteins to said support and said filter means having a porosity such as to prevent passage of said gel support therethrough as said treated blood is withdrawn from said recipient means. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14)
- 0 and pre-β
Specification