Poly(alkylene oxalate) absorbable coating for sutures

• US 4,105,034 A
• Filed: 06/10/1977
• Issued: 08/08/1978
• Est. Priority Date: 06/10/1977
• Status: Expired due to Term

• Current Assignee: Ethicon Incorporated (Johnson & Johnson)
• Original Assignee: Ethicon Incorporated (Johnson & Johnson)
• Inventors: Shalaby, Shalaby W., Jamiolkowski, Dennis D.
• Primary Examiner(s): Padgett, Benjamin R.
• Assistant Examiner(s): Nucker, Christine M.
• Application Number:
  US05/805,501
• Time in Patent Office: 424 Days
• Field of Search: 128/335.5, 424/19, 427/2, 428/375, 428/378
• US Class Current: 606/230
• CPC Class Codes: A61L 17/145 Coating
• CPC Class Codes: Y10T 428/2933 Coated or with bond, impregnation or core
• CPC Class Codes: Y10T 428/2938 Coating on discrete and individual rods, strands or filaments

Abstract

The tie-down properties of multifilament surgical sutures are improved by coating the suture with an absorbable composition comprising a poly(alkylene oxalate) wherein the alkylene is a C₆ or a mixture of C₄ to C₁₂ alkylene moieties. Braided sutures coated with from about 1 to 15 percent by weight of the composition are characterized by a smooth knot tie-down under both wet and dry conditions.

Claims

1. A synthetic, multifilament suture having improved tie-down properties, said suture being coated with from about 1 to 15 percent by weight of a composition comprising a poly(alkylene oxalate) wherein the alkylene is C₆ or a mixture of C₄ - to C₁₂ -alkylene moieties, said poly(alkylene oxalate) having a melting point below about 100°

C and an inherent viscosity of from about 0.1 to 1.2 as determined at 25°

C on a 0.1 percent solution of polymer in CHCl₃ or hexafluoroisopropanol.

2. A suture of claim 1, wherein the multifilament suture is of a braided construction.

3. A suture of claim 1, wherein said poly(alkylene oxalate) is poly(hexamethylene oxalate).

4. A suture of claim 1, wherein the poly(alkylene oxalate) comprises C₄ -, C₆ -, and C₈ -alkylene oxalate moieties.

5. A suture of claim 4, wherein the C₆ -alkylene oxalate comprises from about 30 to 80 percent of the total poly(alkylene oxalate), and the C₄ - and C₈ -alkylene oxalates each comprise from about 10 to 40 percent of the total poly(alkylene oxalate).

6. A suture of claim 1 wherein the poly(alkylene oxalate) comprises C₄ -, C₆ -, C₈ -, and C₁₂ -alkylene oxalate moieties.

7. A suture of claim 6 wherein the C₄ -, C₆ -, C₈ -, and C₁₂ -alkylene oxalates each comprise from about 10 to 40 percent of the total poly(alkylene oxalate).

8. A suture of claim 1 wherein the poly(alkylene oxalate) comprises C₄ - and C₁₀ -alkylene oxalate moieties.

9. A suture of claim 8 wherein the C₄ - and C₁₀ -alkylene oxalates each comprise from about 10 to 90 percent of the total poly(alkylene oxalate).

10. A suture of claim 1 wherein the poly(alkylene oxalate) comprises C₄ - and C₈ -alkylene oxalate moieties.

11. A suture of claim 10 wherein the C₄ - and C₈ -alkylene oxalates each comprise from about 10 to 90 percent of the total poly(alkylene oxalate).

12. A suture of claim 1 wherein the poly(alkylene oxalate) comprises C₄ - and C₆ -alkylene oxalate moieties.

13. A suture of claim 12 wherein the C₄ - and C₆ -alkylene oxalates each comprise from about 10 to 90 percent of the total poly(alkylene oxalate).

14. A suture of claim 1 wherein the poly(alkylene oxalate) comprises C₆ - and C₁₀ -alkylene oxalate moieties.

15. A suture of claim 14 wherein the C₆ - and C₁₀ -alkylene oxalates each comprise from about 10 to 90 percent of the total poly(alkylene oxalate).

16. A suture of claim 1 wherein the poly(alkylene oxalate) comprises C₆ - and C₈ - alkylene oxalate moieties.

17. A suture of claim 16 wherein the C₆ - and C₈ -alkylene oxalates each comprise from about 10 to 90 percent of the total poly(alkylene oxalate).

18. A suture of claim 1 coated with from about 5 to 10 percent of the said composition.

19. A suture of claim 2 wherein the synthetic absorbable suture is comprised of homopolymers or copolymers of lactide and glycolide.

20. A suture of claim 19 wherein said suture is comprised of a copolymer derived from 10 weight percent lactide and 90 weight percent glycolide.

21. A suture of claim 20 wherein the multifilament suture is a braided suture.

22. A suture of claim 2 wherein the synthetic absorbable suture is comprised of poly(p-dioxanone).

23. A suture of claim 22 wherein the multifilament suture is of a braided construction.

24. A method for improving the tie-down characteristics of a multifilament suture which comprises coating said suture with from about 1 to 15 percent by weight of a composition comprising a poly(alkylene oxalate) wherein the alkylene is C₆ or a mixture of C₄ to C₁₂ alkylene moieties, said poly(alkylene oxalate) having a melting point below about 100°

C and an inherent viscosity of from about 0.1 to 1.2 as determined at 25°

C on a 0.1 percent solution of polymer in CHCl₃ or hexafluoroisopropanol.

25. The method of claim 24 wherein the poly(alkylene oxalate) is poly(hexamethylene oxalate).

26. The method of claim 24 wherein the poly(alkylene oxalate) comprises alkylene oxalate moieties selected from the group consisting of C₄ - and C₆ -, C₄ - and C₈ -, C₄ - and C₁₀ -, C₆ - and C₈ -, and C₆ - and C₁₀ -alkylene oxalates.

27. The method of claim 26 wherein each alkylene oxalate is present in an amount equal to from about 10 to 90 percent of the total poly(alkylene oxalate).

28. The method of claim 24 wherein the poly(alkylene oxalate) comprises C₄ -, C₆ - and C₈ -alkylene oxalate moieties.

29. The method of claim 28 wherein the C₆ -alkylene oxalate comprises from about 30 to 80 percent of the total poly(alkylene oxalate) and the C₄ - and C₈ -alkylene oxalates each comprise from about 10 to 40 percent of the total poly(alkylene oxalate).

30. The method of claim 24 wherein the poly(alkylene oxalate) comprises C₄ -, C₆ -, C₈ -, and C₁₂ -alkylene oxalate moieties.

31. The method of claim 30 wherein the C₄ -, C₆ -, C₈ -, and C₁₂ -alkylene oxalates each comprise from about 10 to 40 percent of the total poly(alkylene oxalate).

32. The method of claim 24 wherein said suture is composed of an absorbable synthetic polymer selected from the group consisting of homopolymers and copolymers of lactide and glycolide.

33. The method of claim 24 wherein said suture is composed of poly(p-dioxanone).