1-Aminoalkylpiperidine derivatives

• US 4,105,771 A
• Filed: 06/09/1977
• Issued: 08/08/1978
• Est. Priority Date: 06/23/1976
• Status: Expired due to Term

• Current Assignee: John Wyeth & Brother Limited (Pfizer Inc.)
• Original Assignee: John Wyeth & Brother Limited (Pfizer Inc.)
• Inventors: Archibald, John L., Wart, Terence J.
• Primary Examiner(s): Milestone, Norma S.
• Application Number:
  US05/805,203
• Time in Patent Office: 425 Days
• Field of Search: 260/293.77, 424/267
• US Class Current: 514/329
• CPC Class Codes: C07D 211/58 attached in position 4

Abstract

This invention relates to compounds having the formula ##STR1## and the pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein R represents phenyl or phenyl substituted by halogen, lower alkyl, hydroxy, trifluoromethyl or lower alkoxy; n represents 0 or 1 and m represents 2 or 3 with the proviso that n plus m equals 3; and R¹ represents phenyl, thienyl, pyridyl, furyl, indolyl or phenyl substituted by halogen, lower alkyl, lower alkoxy, trifluoromethyl or hydroxy, which exhibit antihypertensive activity in warm blooded animals.

Claims

1. A compound having the formula ##STR6## and the pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein NHCOR¹ is in the 4-position;

R represents phenyl or phenyl substituted by halogen, lower alkyl, hydroxy, trifluoromethyl or lower alkoxy;

n represents 0 or 1 and m represents 2 or 3 with the proviso that n plus m equals 3; and

R¹ represents phenyl or phenyl substituted by halogen, lower alkyl, lower alkoxy, trifluoromethyl or hydroxy.

2. A compound according to claim 1 wherein R is phenyl, hydroxyphenyl, loweralkylphenyl or lower alkoxy phenyl.

3. A compound according to claim 1 wherein R¹ is phenyl, halophenyl, loweralkoxyphenyl or lower alkylphenyl.

4. A compound according to claim 1 wherein n is 0 and m is 3.

5. A compound according to claim 1 which is 4-benzamido-1-(4-amino-4-phenylbutyl)piperidine.

6. An antihypertensive pharmaceutical composition comprising a therapeutically effective amount of a compound as claimed in claim 1 or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof together with a pharmaceutically acceptable carrier.