Derivatives of 5-(indol-3-yl)hydantoin
First Claim
1. A compound having the formula, ##STR23## or a nontoxic, pharmacologically compatible salt thereof, in which:
- A is a hydrogen atom, a halogeno, a hydroxyl, an alkyl, or an alkoxyl radical, the latter two of which contain 1-4 carbon atoms;
n is 0 or 1;
R is a hydrogen atom or a phenyl radical;
X is a methylene, ethylene, trimethylene, or 2-hydroxytrimethylene radical; and
Z is a morpholino, piperid-1-yl, 4-phenylpiperid-1-yl or 4-hydroxy-4-phenylpiperid-1-yl.
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Abstract
Derivatives of 5-(indol-3-yl)hydantoin characterized by the generic structural formula, ##STR1## and their pharmacologically compatible salts are useful in the treatment of cardiac arrythmias in individuals for whom such therapy is indicated. In the preceding structural formula, A is a hydrogen atom, a halogeno, alkyl, hydroxyl, or an alkoxyl radical; n is 0 or 1; R is a hydrogen atom or a phenyl group; X is a methylene, ethylene, trimethylene, or 2-hydroxytrimethylene radical; and Z is a monoalkylamino radical containing 1-4 carbon atoms, a dialkylamino radical containing 2-8 carbon atoms, a morpholino, piperid-1-yl, 4-phenyl-piperid-1-yl, or a 4-hydroxy-4-phenyl-piperid-1-yl radical.
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Citations
21 Claims
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1. A compound having the formula, ##STR23## or a nontoxic, pharmacologically compatible salt thereof, in which:
- A is a hydrogen atom, a halogeno, a hydroxyl, an alkyl, or an alkoxyl radical, the latter two of which contain 1-4 carbon atoms;
n is 0 or 1; R is a hydrogen atom or a phenyl radical; X is a methylene, ethylene, trimethylene, or 2-hydroxytrimethylene radical; and Z is a morpholino, piperid-1-yl, 4-phenylpiperid-1-yl or 4-hydroxy-4-phenylpiperid-1-yl. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- A is a hydrogen atom, a halogeno, a hydroxyl, an alkyl, or an alkoxyl radical, the latter two of which contain 1-4 carbon atoms;
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2. A compound having the formula, ##STR24## or a nontoxic, pharmacologically compatible salt thereof, in which:
- A'"'"' is a hydrogen atom, a halogeno or an alkoxyl radical containing 1-4 carbon atoms;
n is 0 or 1; R is a hydrogen atom or a phenyl radical; X'"'"' is a trimethylene or a 2-hydroxy-trimethylene radical; and Z is a morpholino, piperid-1-yl, 4-phenylpiperid-1-yl or 4-hydroxy-4-phenylpiperid-1-yl.
- A'"'"' is a hydrogen atom, a halogeno or an alkoxyl radical containing 1-4 carbon atoms;
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20. 5-[(Indol-3-yl)methyl]-3-[3-(piperid-1-yl)propyl]hydantoin.
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21. 5-[Indol-3-yl)methyl]-3-[3-(piperid-1-yl)propyl]hydantoin oxalate.
Specification
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- Resources
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Current AssigneeMiles Laboratories, Inc. (Bayer AG)
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Original AssigneeMiles Laboratories, Inc. (Bayer AG)
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InventorsStrycker, Wallace G., Havera, Herbert J.
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Primary Examiner(s)Jiles, Henry R.
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Assistant Examiner(s)Ramsuer, R. W.
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Application NumberUS05/788,154Time in Patent Office498 DaysField of Search544/139, 260/293.61US Class Current544/139CPC Class CodesC07D 211/52 having an aryl radical as t...
