Neutron irradiation therapy machine

• US 4,112,306 A
• Filed: 12/06/1976
• Issued: 09/05/1978
• Est. Priority Date: 12/06/1976
• Status: Expired due to Term

• Current Assignee: Varian Associates, Inc. (Siemens AG)
• Original Assignee: Varian Associates, Inc. (Siemens AG)
• Inventors: Nunan, Craig S.
• Primary Examiner(s): Dixon, Harold A.
• Application Number:
  US05/748,020
• Time in Patent Office: 638 Days
• Field of Search: 250/499, 328/234
• US Class Current: 376/112
• CPC Class Codes: A61N 2005/109 Neutrons
• CPC Class Codes: A61N 5/10 X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy A61N5/01 takes precedence
• CPC Class Codes: A61N 5/1081 Rotating beam systems with a specific mechanical construction, e.g. gantries
• CPC Class Codes: G21K 1/02 using diaphragms, collimators
• CPC Class Codes: G21K 5/10 with provision for relative movement of beam source and object to be irradiated
• CPC Class Codes: H05H 13/00 Magnetic resonance accelerators; Cyclotrons strophotrons, turbine tubes H01J25/62
• CPC Class Codes: H05H 6/00 Targets for producing nuclear reactions supports for targets or objects to be irradiated G21K5/08 ; preparation of tritium C01B4/00; targets, e.g. pellets for fusion reactions by laser or charged particles beam injection H05H1/22

Abstract

In a neutron irradiation therapy machine for treating patients with a beam of high energy neutrons, a gantry is provided which supports a non-superconducting cyclotron proton accelerator and target for generating a neutron beam and which permits rotation of the accelerator and neutron beam around an axis of revolution coaxial with a patient treatment zone. A counter-weight is carried from the gantry in a diametrically opposed relation to the cyclotron and behind the support bearing for counter-weighting the cyclotron and its associated equipment rotationally and longitudinally. The cyclotron includes an enclosing magnetic return yoke having a re-entrant portion in axial alignment with the magnetic poles of the cyclotron for reducing the weight of the yoke. The enclosing magnetic return yoke, and any additional surrounding material such as boron loaded polyethylene and lead, provide radiation shielding to protect the patient. An alternative patient table is coaxially mounted of the gantry and supported from a rotor portion thereof via a bearing assembly so that the rotor rotates around the stationary patient table. A neutron beam stopper is carried from the rotator of the gantry in axial alignment with the neutron beam and diametrically opposed to the cyclotron for absorbing neutrons passing through the patient treatment zone. Evacuable radio frequency transmission lines are provided for feeding RF power to the cyclotron and which pass through the yoke and are connected in gas communication with a vacuum pump for evacuating the cyclotron via the intermediary of the RF transmission lines. The cyclotron accelerates a beam of charge particles, such as protons, to relatively high energy, as of 30 MeV, to bombard a target formed of first and second materials. The first target material has a relatively high yield for high energy neutrons at proton energies in excess of 15 MeV, whereas a second portion of the target has a low yield for neutrons at proton energies less than 15 MeV, for stopping the protons. Tungsten shielding elements are disposed surrounding the neutron producing target and other regions for attenuation of neutrons falling outside of the desired neutron beam lobe. An adjustable and rotatable neutron beam collimator is arranged for varying the orientation and cross sectional dimensions of the neutron beam as applied to the patient treatment zone.

Claims

1. In a neutron irradiation therapy machine for treating patients with a beam of neutrons:

cyclotron means for accelerating protons to a high energy and for bombarding a target to generate a beam of high energy neutrons to be applied to the patient, said cyclotron means having magnet means for generating a magnetic field for interaction with the protons, said magnet means including a pair of pole portions spaced apart to define a magnetic gap therebetween and within which the magnetic field of said magnet means produces a force on said protons, said magnet means having a yoke means of ferromagnetic material interconnecting said pair of pole portions for providing a relatively low reluctance magnetic flux path for returning the magnetic flux to the respective pole portions, magnetomotive force generating mean coupled in magnetic flux exchanging relation with said pole portions for generating a magnetomotive force and for exciting said magnetic pole portions to opposite magnetic polarities,

proton source means for supplying protons to the region between said pole portions to be accelerated to an energy in excess of 15 MeV, and

gantry means for pivoting said cyclotron about a patient treatment region,

neutron filter means disposed in the neutron beam between the target and the patient treatment region for attenuating relatively low energy neutrons of the beam.

2. The apparatus of claim 1 wherein said neutron filter means has an attenuation coefficient that falls off radially from the center of the beam whereby the uniformity of the neutron intensity is increased laterally of the field of neutron beam irradiation.

3. In a neutron irradiation therapy machine for treating patients with a beam of neutrons:

cyclotron means for accelerating charged particles to a high energy and for bombarding a target to generate a beam of high energy neutrons to be applied to the patient, said cyclotron means having magnet means for generating a magnetic field for interaction with the charged particles, said magnet means including a pair of pole portions spaced apart to define a magnetic gap therebetween and within which the magnetic field of said magnet means produces a force on said charged particles, said magnet means having a yoke means of ferromagnetic material interconnecting said pair of pole portions for providing a relatively low reluctance magnetic flux path for returning the magnetic flux to the respective pole portions, non-superconducting magnetomotive force generating means coupled in magnetic flux exchanging relation with said pole portions for generating a magnetomotive force and for exciting said magnetic pole portions to opposite magnetic polarities, said magnetic yoke means generally enveloping said pole portions,

gantry means for pivoting said cyclotron about an axis of revolution, said gantry means including a bearing structure having, a fixed stator portion and a rotor portion coupled to said cyclotron means for rotationally supporting said cyclotron means as said cyclotron means moves about said axis of revolution, support means for fixedly supporting said stator portion from a platform,

patient table means supportively mounted from said rotor portion and extending generally parallel to said axis of revolution, and a second bearing structure rotationally supporting said patient table means from said rotor and permitting movement of said cyclotron about said patient table while retaining the position of said patient table fixed.

4. The apparatus of claim 3 including counterweight means mounted to said rotor portion in diametrically opposed relation to said cyclotron means for rotation with said rotor portion and for counterweighting the weight of said cyclotron means.

5. The apparatus of claim 3 including beam stopper means carried by said rotor portion in diametrically opposed relation to said cyclotron means and in the neutron beam for absorbing neutrons of the beam after passage thereof through the patient treatment zone.

6. The apparatus of claim 5 wherein said beam stopper means is made of pressed wood particles.

7. In a neutron irradiation therapy machine for treating patients with a beam of neutrons:

cyclotron means for accelerating charged particles to a high energy and for bombarding a target to generate a beam of high energy neutrons to be applied to the patient, said cyclotron means having magnet means for generating a magnetic field for interaction with the charged particles in said cyclotron means, said magnet means including a pair of pole portions spaced apart to define a magnetic gap therebetween and within which the magnetic field of said magnet means produces a force on said charged particles, said magnet means having a yoke means of ferromagnetic material interconnecting said pair of pole portions for providing a relatively low reluctance magnetic flux path for returning the magnetic flux to the respective pole portions, magnetomotive force generating means coupled in magnetic flux exchanging relation with said pole portions for generating a magnetomotive force and for exciting said magnetic pole portions to opposite magnetic polarities, said yoke means generally enveloping said pole portions, said cyclotron means including envelope means for defining an evacuable envelope within which said charged particles are accelerated, electrode means within said envelope to be excited with radio frequency power to produce a radio frequency electric field within said envelope for acting on said charged particles for acceleration thereof to high velocity, radio frequency transmission line means having an evacuable portion passing through said envelope means for transmitting radio frequency power from a source disposed external of said magnet means to said electrode means for excitation thereof, means for coupling a vacuum pump in gas communication with the interior of said envelope means via the intermediary of at least a portion of said evacuable radio frequency transmission line means for evacuation of said envelope means via at least a portion of said evacuable radio frequency transmission line means.

8. The apparatus of claim 7 wherein said transmission line means comprises a section of coaxial line having an outer electrical conductive tubular portion and a centrally disposed longitudinally directed inner electrically conductive portion.

9. In a neutron irradiation therapy machine for treating patients with a beam of neutrons:

accelerator means for accelerating charged particles to a high energy and for bombarding a target to generate a beam of high energy neutrons to be applied to the patient,

target means to be bombarded by said charged particles having an energy substantially greater than 15 MeV to produce a resultant stream of high energy neutrons, and wherein said target includes first and second constituent materials, said first constituent material comprising a relatively high neutron yield material when bombarded with protons of an energy greater than 15 MeV and said second target constituent material comprising a relatively low neutron yield material when bombarded with protons of an energy below 15 MeV.

10. The apparatus of claim 9 wherein said first constituent material of said target is selected from the group consisting of beryllium, lithium and carbon-13.

11. The apparatus of claim 9 wherein said second constituent material of said target is selected from the group consisting of carbon, graphite and gold.

12. The apparatus of claim 9 wherein said first constituent material of said target is selected from the group consisting of beryllium, lithium and carbon-13, and said second constituent material of said target is selected from the group consisting of carbon, graphite and gold.

13. The apparatus of claim 9 including means for rotating said target.

14. The apparatus of claim 13 including means for directing a fluid coolant through said rotatable target in heat exchanging relation therewith for cooling of said target in use.

15. In a neutron irradiation therapy machine for treating patients with a beam of neutrons:

accelerator means for accelerating charged particles to a high energy and for bombarding a target to generate a beam of high energy neutrons to be applied to the patient;

target means to be bombarded by the high energy charged particles to produce the resultant beam of high energy neutrons, shield means disposed adjacent said target means in neutron shielding relation thereto and having a charged particle passageway therein for passage of high energy charged particles through said shield means into said target means, and having a neutral particle exit passageway therein for passage of neutrons emanating from the target through said shield means in the direction of the neutron beam.

16. The apparatus of claim 15 wherein said shield means is made of tungsten.

17. The apparatus of claim 16 wherein said charged particle beam entrance passageway and said neutron beam exit passageway comprises a slot in said shield means, said accelerator means including a magnet means for generating a magnetic field in a gap between a pair of magnetic pole portions enclosed by an evacuable ferromagnetic yoke, said slot lying in a plane coplanar with a plane between said pair of pole portions, and including a second neutron shield means disposed inside of said yoke adjacent a main lobe of neutron flux emanating from said target and in a plane coplanar with said slot in said first shield means for shielding neutrons passing through said first slot means and straying out of the desired neutron beam.

18. The apparatus of claim 17 wherein said second shield means is made of tungsten.

19. In a neutron irradiation therapy machine for treating patients with a beam of neutrons:

cyclotron means for accelerating charged particles to a high energy and for bombarding a target to generate a beam of high energy neutrons to be applied to the patient, said cyclotron means having magnet means for generating a magnetic field for interaction with the charged particles, said magnet means including a pair of pole portions spaced apart to define a magnetic gap therebetween and within which the magnetic field of said magnet means produces a force on said charged particles, said magnet means including a yoke means of ferromagnetic material interconnecting said pair of pole portions for providing a relatively low reluctance magnetic flux path for returning the magnetic flux to the respective pole portions, magnetomotive force generating means coupled in magnetic flux exchanging relation with said pole portions for generating a magnetomotive force and for exciting said magnetic pole portions to opposite magnetic polarities, said yoke means generally enveloping said pole portions,

collimator means disposed in the neutron beam path downbeam from said target for collimating the beam of neutrons to be applied to the patient treatment zone;

said collimator means including a neutron absorbing means having a neutron beam passageway therein, and means for varying the size of said neutron beam passageway for varying the cross sectional area of the neutron beam as applied to the patient treatment zone.

20. The apparatus of claim 19 wherein said means for varying the size of said neutron beam passageway includes a set of neutron absorbing jaw means spaced about the periphery of the neutron beam for defining the cross sectional size of said neutron beam passageway, and means for moving said jaw means radially relative to the central axis of said neutron beam path for varying the size of said neutron beam passageway.

21. The apparatus of claim 20 wherein said neutron absorbing jaw means are made of tungsten.

22. The apparatus of claim 20 including a plurality of said sets of neutron absorbing jaw means arranged serially along the neutron beam path.

23. The apparatus of claim 20 including means for absorbing low energy neutrons in said collimator.

24. The apparatus of claim 23 wherein said means for absorbing low energy neutrons is made of a material selected from the group of pressed wood particles and polyethylene.

25. The apparatus of claim 19 wherein said yoke means includes a neutron beam bore therein in alignment with said neutron beam, and wherein said collimator means is mounted within said neutron beam bore and said yoke means.

26. The apparatus of claim 20 including, means for rotating said collimator means about an axis of revolution intersecting the central axis of said neutron beam.