Certain pyrido-pyrimidines for treating mammalian and avian infections
First Claim
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1. A method of treating an infection in a mammalian or avian host caused by E. coli which utilizes de novo synthesis of riboflavin which comprises the step of administering to a mammalian or avian host having an infection caused by E. coli which utilizes de novo synthesis of riboflavin a therapeutically effective treatment dose for said infection of a compound of formula B ##STR15## where R1 is alkyl or hydroxyalkyl having 1 to 6 carbon atoms, and wherein R2, R3 and R4 are the same or different and each is hydrogen or alkyl of 1 to 4 carbon atoms or a pharmaceutically acceptable salt thereof.
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Abstract
8-Substituted pyrido [2,3-d]pyrimidines having activity against microorganisms which utilize de novo synthesis of riboflavin.
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3 Claims
- 1. A method of treating an infection in a mammalian or avian host caused by E. coli which utilizes de novo synthesis of riboflavin which comprises the step of administering to a mammalian or avian host having an infection caused by E. coli which utilizes de novo synthesis of riboflavin a therapeutically effective treatment dose for said infection of a compound of formula B ##STR15## where R1 is alkyl or hydroxyalkyl having 1 to 6 carbon atoms, and wherein R2, R3 and R4 are the same or different and each is hydrogen or alkyl of 1 to 4 carbon atoms or a pharmaceutically acceptable salt thereof.
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