Non-thrombogenic medical article and a method for its preparation
First Claim
1. A medical article for use in contact with blood having a surface coating containing heparin to prevent thrombosis upon contact with blood, said surface coating also containing Schiff'"'"'s bases with low solubility formed by the reaction of a dialdehyde and a primary amine, the molecules of said Schiff'"'"'s bases being interspersed between the heparin molecules having partially blocked anionic groups in said surface coating to prevent substantial release of heparin from said surface coating upon contact with blood.
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Accused Products
Abstract
A medical article is made non-thrombogenic by means of a surface coating containing heparin. The heparinized surface is stabilized by being contacted first with a cationic surfactant of the primary amine type and, subsequently, with a dialdehyde.
83 Citations
25 Claims
- 1. A medical article for use in contact with blood having a surface coating containing heparin to prevent thrombosis upon contact with blood, said surface coating also containing Schiff'"'"'s bases with low solubility formed by the reaction of a dialdehyde and a primary amine, the molecules of said Schiff'"'"'s bases being interspersed between the heparin molecules having partially blocked anionic groups in said surface coating to prevent substantial release of heparin from said surface coating upon contact with blood.
- 6. The method of stabilizing a heparinized surface to prevent release of heparin upon contact with blood, comprising treating the heparin with a cationic primary amine surfactant to block the anionic groups of the heparin and contacting the surface containing such blocked heparin with a dialdehyde to form in said surface Schiff'"'"'s bases having a low solubility and to partially unblock the anionic groups of the heparin.
Specification