Device for the repeated reproducible delivery of definite variable amounts by volume

• US 4,120,205 A
• Filed: 07/19/1977
• Issued: 10/17/1978
• Est. Priority Date: 07/22/1976
• Status: Expired due to Term

• Current Assignee: Merck Patent GmbH (Merck & Co., Inc.)
• Original Assignee: Merck Patent GmbH (Merck & Co., Inc.)
• Inventors: Ripphahn, Johannes, Kriegbaum, Ernst
• Primary Examiner(s): Yasich, Daniel M.
• Application Number:
  US05/816,977
• Time in Patent Office: 455 Days
• Field of Search: 73/425.6, 73/425.4 P, 222/309, 222/148
• US Class Current: 73/864.13
• CPC Class Codes: B01L 3/022 Capillary pipettes, i.e. having very small bore B01L3/0224 - B01L3/0237 take precedence

Abstract

A combined micrometer screw and syringe assembly with variable predeterminable settings providing for the repeated, exactly reproducible delivery of predetermined variable volumetric amounts of liquid from the syringe but with permissive interim availability of the entire volume of the syringe for rinsing and cleaning thereof without altering any predetermined setting for the definite amount to be delivered therefrom.

Claims

1. Apparatus adapted for variable predeterminable settings to effect the repeated, reproducible delivery of definite volumetric amounts of liquid, and with permissive interim cleaning of the apparatus without altering the predetermined delivery setting thereof;

and comprising a syringe cylinder and piston assembly having a piston with actuating means for the piston;

a micrometer screw assembly;

mounting means connecting the said assemblies for relative movement therebetween, and stop means adjustably located by said micrometer screw assembly to a pre-selected position for limiting the intake stroke of the syringe piston in accordance with the predetermined setting of the micrometer screw assembly as determined by the preselected volume to be delivered from the syringe cylinder on the exhaust stroke of the syringe piston, and another position upon relative movement of said assemblies with the stop means shiftable to permit full intake and exhaust strokes of the syringe piston, as for interim cleaning or rinsing of the syringe cylinder, without altering the predetermined setting of the stop means by the micrometer screw assembly upon return to the pre-selected position of the assemblies.

2. Apparatus according to claim 1, wherein the mounting means includes central tube means on which a sleeve carrying the micrometer screw assembly is mounted for movement between a position in which the intake stroke of the syringe piston is limited, as pre-selected, and a position permitting full strokes of the syringe piston.

3. Apparatus according to claim 2, wherein the syringe cylinder is secured by a clamping collar to the lower end of the tube means and within which tube means a syringe piston guide is mounted for controlled sliding movement as actuated by the piston actuating means projecting outwardly through a slot in the tube means.

4. Apparatus according to claim 3, wherein the sleeve carrying the micrometer screw assembly is rotatable and slidable on the tube means and provided with a pin extending into a bayonet type slot with upper and lower transverse slots into which the pin fits at the upper and lower limits of the axial displacement of the sleeve.

5. Apparatus according to claim 4, wherein the upper limit of displacement of the sleeve is additionally fixed by a ball and socket connection between the sleeve and the tube means.

6. Apparatus according to claim 1, wherein the mounting means includes upper and lower connected members each provided with a central longitudinal bore and wherein the micrometer screw assembly includes a spindle projectable into the upper bore and forming at least a part of the stop means.

7. Apparatus according to claim 6, wherein the stop means further includes a push rod interposed between the micrometer screw spindle and the adjacent end of the syringe piston and guided for movement in the upper and lower bores.

8. Apparatus according to claim 7, wherein the push rod is spring urged for one end contact with the micrometer screw assembly, and with the opposite end providing an adjustable contact stop limiting the intake stroke of the syringe piston to the pre-selected position.

9. Apparatus according to claim 8, wherein the push rod is provided with hardened contact balls at opposite ends thereof.

10. Apparatus according to claim 1, wherein the mounting means includes a sleeve carrying the micrometer screw assembly and shiftable relative to the mounting means to initiate release of the micrometer screw assembly from the pre-selected position in which the piston stroke is limited to another position permitting full strokes of the piston.

11. Apparatus according to claim 1, wherein the mounting means includes a sleeve carrying the micrometer screw assembly and shiftable relative to the mounting means with the syringe piston and micrometer screw assembly maintained on a common axis as the micrometer screw assembly is shifted from the pre-selected position in which the piston stroke is limited to another position permitting full stroke of the piston.