Machine for introducing measured amounts of liquids into vials and other receptacles

• US 4,135,561 A
• Filed: 07/20/1977
• Issued: 01/23/1979
• Est. Priority Date: 07/20/1976
• Status: Expired due to Term

• Current Assignee: Henri Senelonge
• Original Assignee: Henri Senelonge
• Inventors: Senelonge, Henri
• Primary Examiner(s): Bell, Houston S.
• Application Number:
  US05/817,427
• Time in Patent Office: 552 Days
• Field of Search: 141/82, 141/100, 141/231, 141/232, 141/234, 141/237, 141/238, 141/240, 141/242, 141/243, 141/244, 141/18, 141/329, 141/330, 141/DIG. 1, 222/146 H, 222/255, 417/271
• US Class Current: 141/234
• CPC Class Codes: G01N 2035/0425 Stacks, magazines or elevators for plates
• CPC Class Codes: G01N 2035/0486 Gearing, cams
• CPC Class Codes: G01N 35/1004 Cleaning sample transfer devices
• CPC Class Codes: G01N 35/1065 Multiple transfer devices
• CPC Class Codes: G01N 35/1083 with one horizontal degree of freedom

Abstract

A generally vertical frame has a pair of columns on which an upper support and a lower support are slidably mounted, the lower support carrying the barrels of a row of syringes whose plungers are fastened to the upper support. The latter support can be alternately lowered and raised, manually by a lever or automatically by a cam, and is connected with the lower support by a lost-motion linkage allowing the two supports to be separated to an extent sufficient for a partial withdrawal of the plungers from their barrels when the syringes are dipped into one or more supply containers on a base onto which the lower support is held by a strong magnetic coupling until entrained by the rising upper support. Upon alignment of the elevated syringes with a row of receptacles to be filled, an interposed stop arrests their barrels while the plungers descend with the lower support to expel the previously aspirated liquids until the two supports come into contact with each other, whereupon a weaker magnetic coupling therebetween causes their joint ascent preparatorily to the next syringe-refilling operation. The frame may be swingable about a horizontal axis for alternate alignment of the syringes with the supply containers and the receptacles which can be arrayed in one or more rows.

Claims

1. A machine for introducing measured amounts of liquids into a set of receptacles, comprising:

a base carrying upwardly open container means filled with a supply of liquid;

a mounting disposed above said base;

an upper support and a lower support guided on said mounting for generally vertical reciprocation;

a set of horizontally spaced-apart syringes with barrels carried on said lower support and with plungers carried on said upper support, said supports being provided with first retaining means for releasably holding said supports together to hold said plungers fully inserted into said barrels and being interconnected by a lost-motion linkage enabling limited separation of said supports to an extent sufficient for a partial withdrawal of said plungers from said barrels;

operating means connected with said upper support for reciprocating same between a top position and a bottom position with entrainment of said lower support, said barrels dipping into said container means in said bottom position, said lower support and said base being provided with second retaining means capable or overriding said first retaining means for releasably holding said lower support onto said base during part of an ascending stroke of said upper support whereby some of the liquid in said container means is aspirated into said barrels by the rising plungers, said lost-motion linkage disengaging said lower support from said base and elevating the filled barrels during the remainder of said ascending stroke;

holding means carrying receptacles alignable with the filled barrels in their elevated position; and

stop means for keeping said lower support elevated during a subsequent descending stroke of said upper support whereby the contents of said barrels are discharged by said plungers into the receptacles aligned therewith.

2. A machine as defined in claim 1 wherein said mounting is a frame with a pair of columns traversing said supports.

3. A machine as defined in claim 1 wherein said first and second retaining means are a relatively weak and a relatively strong magnetic coupling.

4. A machine as defined in claim 1 wherein said holding means is interposable between said lower support and said base, said stop means comprising an extension on said lower support coming to rest on the interposed holding means.

5. A machine as defined in claim 1 wherein said lost-motion linkage comprises a threaded rod traversing said supports and a nut on said rod enabling adjustment of the maximum separation of said supports.

6. A machine as defined in claim 1 wherein said mounting is swingable about a horizontal axis for alternately aligning said barrels with said container means and with said holding means.

7. A machine as defined in claim 6 wherein said stop means comprises a brace articulated to said lower support and to said base for coming to rest on said holding means upon alignment of said barrels therewith.

8. A machine as defined in claim 6 wherein said operating means comprises first cam means for swinging said mounting about said axis and second cam means synchronized with said first cam means for reciprocating said upper support on said mounting.

9. A machine as defined in claim 8, further comprising spring means for holding a cam follower on said mounting engaged with said first cam means, said second cam means positively engaging a cam follower on said upper support.

10. A machine as defined in claim 8 wherein said recptacles are arrayed on said holding means in a plurality of rows parallel to said axis, further comprising a carriage pivotally supporting said mounting, said carriage being movable relatively to said holding means in a direction perpendicular to said rows, and drive means synchronized with said first and second cam means for successively aligning said barrels in their liquid-filled state with different rows of receptacles.

11. A machine as defined in claim 10 wherein said drive means comprises a stepped cam.

12. A machine as defined in claim 6 wherein said holding means includes a transporter advancing intermittently past said mounting, further comprising hopper means for successively depositing sets of receptacles on said transporter.

13. A machine as defined in claim 1 wherein said container means comprises at least one vessel divided into a main compartment and an overflow compartment, feed means terminating at said main compartment for continously supplying liquid thereto from a source, and drain means extending from said overflow compartment to said source.

14. A machine as defined in claim 13 wherein said feed means comprises a conduit provided with a fluid pump.

15. A machine as defined in claim 14 wherein said conduit is an upwardly open channel, said fluid pump comprising an endless conveyor carrying rollers received in said channel.