Process for preparing dialkyl (p-aminobenzoyl) glutamates
First Claim
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1. A process for the preparation of an ester represented by formula (I):
- ##STR3## wherein R1 is hydrogen or C1 -C4 alkyl and R2 is C1 -C4 alkyl, which comprises reacting a zinc salt of an acid represented by formula (II);
##STR4## wherein R1 is as previously identified, with a C1 -C4 alcohol at ambient temperature in the presence of an inorganic acid to form said ester of formula (I);
diluting the reaction mixture with water;
clarifying the diluted reaction mixture;
alkalizing said clarified reaction mixture to about pH 4-6 to precipitate said ester of formula (I); and
, recovering the same.
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Abstract
A process for the preparation of dialkyl (p-aminobenzoyl) glutamates is disclosed. Dialkyl (p-Aminobenzoyl) glutamates are useful as intermediates in the synthesis of N-{p-([(2,4-diamino-6-pteridinyl)-methyl]methylamino)benzoyl} glutamic acid, also known as 4-amino-N10 -methylpteroylglutamic acid. The compound zinc N-(p-methylaminobenzoyl)-L-(+)-glutamate, is also disclosed.
11 Citations
6 Claims
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1. A process for the preparation of an ester represented by formula (I):
- ##STR3## wherein R1 is hydrogen or C1 -C4 alkyl and R2 is C1 -C4 alkyl, which comprises reacting a zinc salt of an acid represented by formula (II);
##STR4## wherein R1 is as previously identified, with a C1 -C4 alcohol at ambient temperature in the presence of an inorganic acid to form said ester of formula (I);
diluting the reaction mixture with water;
clarifying the diluted reaction mixture;
alkalizing said clarified reaction mixture to about pH 4-6 to precipitate said ester of formula (I); and
, recovering the same. - View Dependent Claims (2, 3, 4, 5)
- ##STR3## wherein R1 is hydrogen or C1 -C4 alkyl and R2 is C1 -C4 alkyl, which comprises reacting a zinc salt of an acid represented by formula (II);
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6. The compound zinc N-(p-methylaminobenzoyl)-L-(+)-glutamate.
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Current AssigneeAmerican Colloid Company (Minerals Technologies Incorporated)
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Original AssigneeAmerican Colloid Company (Minerals Technologies Incorporated)
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InventorsKazan, John
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Primary Examiner(s)Thomas, Jr., James O.
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Assistant Examiner(s)Breitenstein, G. T.
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Application NumberUS05/875,051Time in Patent Office354 DaysField of Search560/41, 260/429.9US Class Current556/133CPC Class CodesC07C 2601/14 The ring being saturated
