Pharmaceutical compositions containing imidazo(2,1-b)thiazoles and process for reducing blood sugar levels therewith

• US 4,137,320 A
• Filed: 10/14/1976
• Issued: 01/30/1979
• Est. Priority Date: 02/07/1974
• Status: Expired due to Term

• Current Assignee: Plantex Ltd.
• Original Assignee: Plantex Ltd.
• Inventors: Tedeschi, Enzo
• Primary Examiner(s): Goldberg, Jerome D.
• Application Number:
  US05/732,356
• Time in Patent Office: 838 Days
• Field of Search: 424/270, 260/306 TT
• US Class Current: 514/368
• CPC Class Codes: A61K 31/425 Thiazoles
• CPC Class Codes: C07D 513/04 Ortho-condensed systems

Abstract

Pharmaceutical compositions containing certain imidazo(2,1-b)thiazoles, their physiologically acceptable acid addition- or quaternary ammonium salts, and a process for reducing blood sugar levels by the administration thereof.

Claims

1. A method for the reduction of the blood sugar level in a patient suffering from diabetes, which comprises administering to said patient an imidazo( 2,1-b)thiazole of the formula:

##STR11## wherein;

A'"'"' is COOR" and R" is hydrogen or lower alkyl;

C'"'"' is methyl, tert.-butyl or phenyl; and

D'"'"' is hydrogen or lower alkyl;

or pharmaceutically acceptable acid salts thereof;

in an amount effective for lowering the blood sugar level.

2. The method of claim 1, wherein the imidazo(2,1-b)thiazole is 3-methyl-imidazo(2,1-b)thiazole-6-carboxylic acid.

3. The method of claim 1, wherein the imidazo(2,1-b)thiazole is 2,3-dimethyl-imidazo(2,1-b)thiazole-6-carboxylic acid.

4. The method of claim 1, wherein the imidazo(2,1-b)thiazole is 2-ethyl-3-methyl-imidazo(2,1-b)thiazole-6-carboxylic acid.

5. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 3-methyl-6-carbomethoxy-imidazo(2,1-b)thiazole.

6. The method of claim 1, wherein the imidazo(2,1-b)thiazole is 3-methyl-6-carboethoxy-imidazo(2,1-b)thiazole.

7. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 3-methyl-6-carbopropoxy-imidazo(2,1-b)thiazole.

8. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 3-methyl-6-carboisopropoxy-imidazo(2,1-b)thiazole.

9. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 3-methyl-6-carbobutoxy-imidazo(2,1-b)thiazole.

10. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 3-methyl-6-carboisobutoxy-imidazo(2,1-b)thiazole.

11. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 3-methyl-6-sec.carbobutoxy-imidazo(2,1-b)thiazole.

12. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 3-t-butyl-6-carbomethoxy-imidazo(2,1-b)thiazole.

13. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 3-phenyl-6-carbomethoxy-imidazo(2,1-b)thiazole.

14. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 2-propyl-6-carbomethoxy-imidazo(2,1-b)thiazole.

15. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 2,3-dimethyl-6-carbomethoxy-imidazo(2,1-b)thiazole.

16. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 2-ethyl-3-methyl-6-carbomethoxy-imidazo(2,1-b)thiazole.

17. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 2-propyl-3-methyl-6-carboethoxy-imidazo(2,1-b)thiazole.

18. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 2-butyl-3-methyl-6-carboethoxy-imidazo(2,1-b)thiazole.

19. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 2-isoamyl-3-methyl-6-carboethoxy-imidazo(2,1-b)thiazole.

20. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 2,3-dimethyl-6-carboethoxy-imidazo(2,1-b)thiazole.

21. The method of claim 1 wherein the imidazo(2,1-b)thiazole is 2-ethyl-3-methyl-6-carboethoxy-imidazo(2,1-b)thiazole.

22. A method for the reduction of the blood sugar level in a patient suffering from diabetes, which comprises administering to said patient 3-p-chlorophenyl-6-carbomethoxy-imidazo(2,1-b)thiazole or a pharmaceutically acceptable acid salt thereof, in an amount effective for lowering the blood sugar level.