Fluid flow control system

• US 4,137,913 A
• Filed: 02/28/1975
• Issued: 02/06/1979
• Est. Priority Date: 02/28/1975
• Status: Expired due to Term

• Current Assignee: IVAC Medical Systems, Inc. (Becton, Dickinson & Co)
• Original Assignee: Ivax Corporation (Teva Pharmaceutical Industries, Ltd.)
• Inventors: Georgi, Heinz W.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US05/554,092
• Time in Patent Office: 1,439 Days
• Field of Search: 128/1 D, 128/214 E, 128/214 F, 128/218 A, 128/DIG. 12, 128/DIG. 13, 128/DIG. 1, 421/9, 421/19, 421/20, 421/44, 421/326, 421/410, 222/63
• US Class Current: 604/67
• CPC Class Codes: A61M 5/14216 Reciprocating piston type
• CPC Class Codes: A61M 5/16809 by repeated filling and emptying of an intermediate volume pressure infusion using positive displacement pumps A61M5/142
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: G05D 7/0676 by action on flow sources G05D7/0688, G05D7/0694 take precedence
• CPC Class Codes: Y10S 128/12 Pressure infusion
• CPC Class Codes: Y10S 128/13 Infusion monitoring

Abstract

A syringe pump operated by a stepping motor to repetitively fill and empty a syringe cartridge over a plurality of operational cycles of successive fill stroke and pump stroke periods. The motor is driven by drive pulses from a digital pulse generation and control system, the pulse frequency establishing a predetermined fixed rate of fill during the fill stroke and being preselected, in accordance with desired output flow rate, to establish the rate at which the syringe is emptied during the pump stroke. The drive pulse rate during a fill stroke exceeds the maximum pulse rate during a pump stroke and, in order to maintain a proportional relationship between the preselected pumping rate and the actual pumping rate over each complete cycle of successive fill and pump strokes, the drive pulse frequency during each pump stroke is automatically increased to compensate for the time lost during each fill stroke. This is accomplished by accelerating counting up of the electrical network defining each individual pump stroke drive pulse period for a time interval equal to a single fill stroke drive pulse period. A start-up subsystem insures proper cartridge installation prior to initiation of a pumping cycle. Appropriate alarms respond to improper operating conditions including leakage from the source during the pump stroke, empty bottle or insufficient flow during fill, air in the I.V. line, a stalled motor, lack of flow due to system component failure, or occurrence of a runaway high pumping rate.

Claims

1. In a system for parenteral administration of liquids at desired flow rates through a feeding tube from a liquid source to a patient, the combination comprising:

syringe means for performing alternate fill and pump strokes to control the flow of liquid through the feeding tube;

motor means for driving said syringe means;

electrical pulsing means for providing output pulses to said motor means at a fill frequency and at a pump frequency to operate said syringe means; and

digital means for automatically varying said pump frequency output pulses as a function of said fill frequency output pulses to achieve the desired flow rate.

2. A combination as set forth in claim 1, wherein said digital means compensates each of the pump frequency output pulse periods during a time interval equal to a fill frequency output pulse period.

3. Apparatus as set forth in claim 1, and further comprising:

detection means responsive to lack of motor rotation within a defined period.

4. Apparatus as set forth in claim 3, and further comprising:

alarm means responsive to said detection means for de-energizing said motor means.

5. Apparatus as set forth in claim 1, and further comprising:

detection means responsive to lack of motor rotation within a prescribed number of said output pulses.

6. Apparatus as set forth in claim 5, and further comprising:

alarm means responsive to said detection means for de-energizing said motor means.

7. In a system for parenteral administration of liquids via a syringe pump, apparatus comprising:

motor means for driving a syringe through successive fill and pump strokes during which the syringe is first filled with liquid and the liquid is subsequently delivered from the syringe;

electrical pulsing means for providing output pulses at a fill frequency and at a pump frequency to operate said motor means in said fill stroke and said pump stroke, respectively; and

electrical control means for automatically varying the pump frequency of said output pulses during said pump stroke, to compensate for time lost during said fill stroke and to achieve the desired flow rate.

8. Apparatus as set forth in claim 7, wherein said electrical control means compensates each of the pump frequency output pulse periods during a time interval equal to a fill frequency output pulse period.

9. Apparatus as set forth in claim 7, wherein said electrical control means spreads the compensation for time lost during said fill stroke uniformly over said pump stroke.

10. Apparatus as set forth in claim 7, wherein said control means includes at least one counter for determining the period between successive pump frequency output pulses.

11. Apparatus as set forth in claim 7, wherein said control means includes a pair of digital counters, one of said counters being a divide-by-two counter, said counters together determining the duration of each pump frequency output pulse.

12. Apparatus as set forth in claim 11, wherein said divide-by-two counter normally controls the counting rate into the other of said pairs of counters.

13. Apparatus as set forth in claim 12, and further comprising:

means for automatically bypassing said divide-by-two counter during generation of each pump frequency output pulse period for a time interval equal to the period between successive fill stroke output pulses.

14. Apparatus as set forth in claim 7, and further including:

a syringe actuator driven by said motor means;

means for detecting the physical presence of a syringe;

means responsive to lack of detection of a syringe for energizing said motor means via said pulsing means to drive said actuator; and

means for sensing a prescribed position of said actuator for de-energizing said motor means, whereby said actuator comes to rest in a position designated as proper for syringe installation.

15. Apparatus as set forth in claim 14, wherein said motor means is a d.c. stepping motor, and said stepping motor is energized by said pulsing means at said fill frequency in response to lack of detection of a syringe.

16. Apparatus as set forth in claim 7, and further comprising:

an intake line through which the syringe is filled with liquid; and

means responsive to lack of liquid flow in said intake line during a fill stroke for generating an alarm state.

17. Apparatus as set forth in claim 7, and further comprising:

means responsive to liquid flow below a prescribed minimum flow rate during a fill stroke for generating an alarm state.

18. Apparatus as set forth in claim 17, and further comprising:

means for delaying the response to said liquid flow below a prescribed minimum flow rate, for a prescribed period of time at the beginning of each fill stroke.

19. Apparatus as set forth in claim 7, and further comprising:

an intake line through which the syringe is filled wtih liquid; and

means responsive to liquid flow in said intake line during a pump stroke for generating an alarm state.

20. Apparatus as set forth in claim 19, and further comprising:

means for delaying the response to said liquid flow, for a prescribed period of time at the beginning of each pump stroke.

21. Apparatus as set forth in claim 7, and further comprising:

alarm means responsive to lack of rotation of said motor means.

22. Apparatus as set forth in claim 21, wherein said alarm means is responsive to lack of rotation within a prescribed number of said output pulses.

23. Apparatus as set forth in claim 7, and further comprising:

means for detecting drop flow; and

means responsive, only at the end of a fill stroke, to a lack of a prescribed number of accumulated drops detected during said fill stroke for generating an alarm state.

24. Apparatus as set forth in claim 7, and further comprising:

means responsive to a high rate of output pulses in excess of those required to achieve said desired flow rate for generating an alarm state.

25. Apparatus as set forth in claim 7, and further comprising:

means for detecting the physical presence of a syringe; and

means for preventing energization of said motor means at other than said fill frequency when no syringe is detected.

26. Apparatus as set forth in claim 7, wherein said control means includes:

counting means for counting up at a normal rate the period between successive pump stroke output pulses; and

means for counting up said period between successive pump stroke output pulses at twice said normal counting rate, for a time interval equal to the period between successive fill stroke output pulses.

27. In a syringe pump including a syringe, apparatus comprising:

driving means for driving the syringe through a fill stroke in which the syringe is filled with fluid through an intake line and through a pump stroke during which fluid is delivered from the syringe through an output line;

detection means responsive to fluid flow below a prescribed drop flow rate through the intake line during said fill stroke; and

means for delaying the response to said prescribed drop flow rate for a pre-established period of time at the beginning of each fill stroke.

28. Apparatus as set forth in claim 27, and further comprising:

alarm means responsive to said detection means for de-energizing said driving means.

29. In a syringe pump including a syringe, apparatus comprising:

driving means for driving the syringe through a fill stroke in which the syringe is filled with fluid through an intake line and through a pump stroke during which fluid is delivered from the syringe through an output line; and

detection means responsive to detection of fluid flow in said intake line during a pump stroke.

30. Apparatus as set forth in claim 29, and further comprising:

alarm means responsive to said detection means for de-energizing said driving means.

31. Apparatus as set forth in claim 29, and further comprising:

means for delaying the response to detection of fluid flow for a prescribed period of time at the beginning of each pump stroke.

32. Apparatus as set forth in claim 31, and further comprising:

alarm means responsive to said detection means for de-energizing said driving means.

33. In a syringe pump, apparatus comprising:

motor means for driving the syringe through a fill stroke in which the syringe is filled with fluid through an input line and through a pump stroke during which fluid is delivered from the syringe through an output line; and

detection means responsive to lack of a prescribed number of accumulated drops detected in said input line at the end of a fill stroke.

34. Apparatus as set forth in claim 33, and further comprising:

alarm means responsive to said detection means for de-energizing said driving means.

35. Apparatus as set forth in claim 34, and further comprising:

means for disabling said detection means in the absence of a syringe.

36. In a syringe pump for delivering fluid at selected flow rates, apparatus comprising:

motor means for driving the syringe through a fill stroke in which the syringe is filled with fluid through an input line and through a pump stroke during which fluid is delivered from the syringe through an output line;

means for generating motor drive pulses to energize said motor means; and

detection means responsive to a high rate of said motor drive pulses in the absence of concurrent high flow rate selected.

37. Apparatus as set forth in claim 36, and further comprising:

alarm means responsive to said detection means for de-energizing said driving means.

38. In a syringe pump including a syringe, apparatus comprising:

means for driving the syringe through a fill stroke in which the syringe is filled with fluid through an intake line and through a pump stroke during which fluid is delivered from the syringe through an output line; and

detection means responsive to fluid flow below a prescribed drop flow rate through the intake line during said fill stroke.

39. Apparatus as set forth in claim 38, and further comprising:

alarm means responsive to said detection means for de-energizing said driving means.

40. In a syringe pump including a syringe, apparatus comprising:

means for driving the syringe through a fill stroke in which the syringe is filled with fluid through an intake line and through a pump stroke during which fluid is delivered from the syringe through an output line;

drop detection means responsive to drop flow in the intake line; and

drop rate discriminator means, responsive to said drop detection means, for sensing fluid flow below a prescribed drop flow rate through the intake line during said fill stroke.

41. In a syringe pump including a syringe, apparatus comprising:

stepping motor means for driving the syringe through a fill stroke in which the syringe is filled with fluid through an input line and through a pump stroke during which fluid is delivered from the syringe through an output line at a selected fluid flow rate;

means for generating motor drive pulses to energize said motor means; and

compensation means for compensating all of said motor drive pulses during said pump stroke for the total time lost during performance of said fill stroke.

42. Apparatus as set forth in claim 41, wherein said compensation means includes:

counting means for counting up the period between successive pump stroke motor drive pulses; and

means for counting up said period between successive pump stroke motor drive pulses, at twice the rate normally called for by the selected fluid flow rate, for a time interval equal to the period between successive fill stroke motor drive pulses.

43. in a syringe pump, the combination comprising:

a syringe actuator;

a stepping motor for driving said actuator;

means for detecting the presence of a syringe;

means responsive to the lack of presence of a syringe for energizing said stepping motor at a prescribed rate to drive said actuator; and

means for sensing a predetermined position of said actuator for de-energizing said stepping motor, whereby a syringe may be installed.

44. In a fluid pumping system for driving a disposable syringe having inlet and outlet ports and a piston slidably received within said syringe, the combination comprising:

means for selecting a desired output fluid flow rate from said syringe;

drive means for reciprocating said syringe piston, said drive means including a d.c. stepping motor;

means for generating motor drive pulses during a fill stroke;

means for generating motor drive pulses during a pump stroke; and

means for compensating the frequency of all of the motor drive pulses during said pump stroke for time lost during said fill stroke.

45. In a syringe pump, apparatus comprising:

motor means for driving the syringe through a fill stroke in which the syringe is filled with fluid through an input line and through a pump stroke during which fluid is delivered from the syringe through an output line;

rate multiplier means;

means for deriving from said rate multiplier means a pump frequency proportional to desired fluid flow rate; and

means for deriving a fixed fill frequency from said rate multiplier means, said fill frequency being in excess of the maximum value of said pump frequency.

46. Apparatus as set forth in claim 45, and further including:

means for resetting the high order rate multiplier decades at the end of each motor drive pulse in the pump stroke.

47. In a fluid pumping system for driving a syringe having inlet and outlet ports and a piston slidably received within said syringe, the combination comprising:

means for selecting a desired output fluid flow rate from said syringe;

drive means for reciprocating said syringe piston through a fill stroke, in which said syringe is filled with fluid through an input line and said inlet port, and through a pump stroke during which fluid is delivered through said outlet port and an output line, said drive means including a d.c. stepping motor;

means for generating motor drive pulses during a fill stroke;

means for generating motor drive pulses during a pump stroke;

counting means for determining the duration of the period between successive pump stroke motor drive pulses; and

means for counting up said period between successive pump stroke motor drive pulses, at twice the rate called for by the selected fluid flow rate, for a time interval equal to the period between successive fill stroke motor drive pulses, whereby the frequency of the motor drive pulses during said pump stroke is uniformly compensated for time lost during said fill stroke.

48. Apparatus as set forth in claim 47, and further comprising:

means responsive to detection of gas bubbles in said input line for generating an alarm state.

49. Apparatus as set forth in claim 47, wherein said drive means includes:

a syringe actuator driven by said stepping motor;

means for detecting the physical presence of said syringe;

means responsive to lack of detection of said syringe for energizing said motor to drive said actuator; and

means for sensing a prescribed position of said actuator for de-energizing said stepping motor, whereby said actuator comes to rest in a position designated as proper for syringe installation.

50. Apparatus as set forth in claim 47, and further comprising:

means responsive to lack of liquid flow in said input line during a fill stroke for generating an alarm state.

51. Apparatus as set forth in claim 47, and further comprising:

means responsive to liquid flow below a prescribed minimum flow rate during a fill stroke for generating an alarm state.

52. Apparatus as set forth in claim 51, and further comprising:

means for delaying the response to said liquid flow below a prescribed minimum flow rate, for a prescribed period of time at the beginning of each fill stroke.

53. Apparatus as set forth in claim 47, and further comprising:

means responsive to liquid flow in said input line during a pump stroke for generating an alarm state.

54. Apparatus as set forth in claim 53, and further comprising:

means for delaying the response to said liquid flow, for a prescribed period of time at the beginning of each pump stroke.

55. Apparatus as set forth in claim 47, and further comprising:

alarm means responsive to lack of rotation of said stepping motor.

56. Apparatus as set forth in claim 55, wherein said alarm means is responsive to lack of rotation within a prescribed number of said motor drive pulses.

57. Apparatus as set forth in claim 47, and further comprising:

means for detecting drop flow; and

alarm means responsive, only at the end of a fill stroke, to a lack of a prescribed number of accumulated drops detected during said fill stroke.

58. Apparatus as set forth in claim 47, and further comprising:

alarm means responsive to a high rate of motor drive pulses during said pump stroke in excess of those required to achieve said desired fluid flow rate.

59. In a fluid pumping system for driving a disposable syringe having inlet and outlet ports and a piston slidably received within said syringe, the combination comprising:

rate multiplier means having a plurality of rate multiplier decades;

variable rate selector switch means connected to said rate multiplier means for establishing a desired output fluid flow rate pump frequency from said rate multiplier means proportional to desired fluid flow rate from said syringe during a pump stroke in which fluid is delivered from said syringe through said outlet port and an outlet line;

means for deriving a fixed fill frequency from said rate multiplier means proportional to a specified flow rate during a fill stroke in which said syringe is filled with fluid through said inlet port and an input line, said fill frequency being in excess of the maximum pump frequency;

means for generating motor drive pulses at said fixed fill frequency during a fill stroke;

means for generating motor drive pulses at a pump frequency during a pump stroke;

counting means for counting up the period between successive pump stroke motor drive pulses;

means for counting up said period between successive pump stroke motor drive pulses, at twice the normal rate called for by the selected fluid flow rate during the pump stroke, for a time interval equal to the period between successive fill stroke motor drive pulses, whereby the frequency of the motor drive pulses to said d.c. stepping motor is compensated during said pump stroke for time lost during said fill stroke; and

means responsive to said counting means for resetting the high order rate multiplier decades at the beginning of each motor drive pulse period in the pump stroke.