3-Cyano-N-(N,N-dimethylaminopropyl)-iminodibenzyl and salts thereof

• US 4,138,482 A
• Filed: 10/11/1977
• Issued: 02/06/1979
• Est. Priority Date: 10/12/1976
• Status: Expired due to Term

• Current Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Original Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Inventors: Dostert, Philippe
• Primary Examiner(s): Daus, Donald G.
• Assistant Examiner(s): Springer, D. B.
• Application Number:
  US05/840,790
• Time in Patent Office: 483 Days
• Field of Search: 260/239 D, 424/244
• US Class Current: 514/217
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 25/26 Psychostimulants, e.g. nicotine, cocaine
• CPC Class Codes: C07D 223/22 Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
• CPC Class Codes: C07D 223/28 having a single bond between positions 10 and 11

Abstract

3-Cyano-N-(N,N-dimethylaminopropyl)-iminodibenzyl, and its salts, prepared, inter alia, by heating 3-cyano-iminodibenzyl-5-carboxylic acid (N,N-dimethylaminopropyl ester) are described. The end product and its salts are useful as antidepressants.

Claims

1. 3-Cyano-N-(N,N-dimethylaminopropyl)-iminodibenzyl or a pharmaceutically acceptable acid addition salt thereof.

2. In accordance with claim 1, 3-cyano-N-(N,N-dimethylaminopropyl)-iminodibenzyl hydrochloride.

3. A pharmaceutical composition for the treatment of depression consisting essentially of an effective amount of 3-cyano-N-(N,N-dimethylaminopropyl)iminodibenzyl or a pharmaceutically acceptable acid addition salt thereof for the treatment of depression in warm-blooded mammals and a pharmaceutically acceptable carrier material.