Implantable dosing device

• US 4,140,121 A
• Filed: 06/02/1977
• Issued: 02/20/1979
• Est. Priority Date: 06/11/1976
• Status: Expired due to Term

• Current Assignee: Siemens AG
• Original Assignee: Siemens AG
• Inventors: Mund, Konrad, Richter, Gerhard, Kuhl, Dieter, Luft, Gunter, Sturm, Ferdinand V.
• Primary Examiner(s): Sebastian, Leland A.
• Application Number:
  US05/802,969
• Time in Patent Office: 628 Days
• Field of Search: 128/130, 128/213, 128/272, 128/260, 424/19, 424/228
• US Class Current: 604/891.1
• CPC Class Codes: A61M 5/14276 specially adapted for implantation

Abstract

The invention relates to an implantable dosing device for the continuous, controllable release of medication in the human or animal body, comprising a medicine reservoir of variable volume and a liquid chamber which is tensionally connected to the medicine reservoir and the volume of which can be varied by liquid which is transported through an ion exchange diaphragm by electro-osmosis due to an electric field between two electrodes. According to the invention, the electrodes in such an implantable dosing device are hydrogen electrodes which are connected to each other by a line for hydrogen, and means are further provided for compensating hydrogen losses.

Claims

1. In an implantable dosing device for the continuous, controllable release of medication in the human or animal body comprised of a medication reservoir of variable volume, a liquid chamber tensionally connected to said medication reservoir, and volume varying means comprised of an ion-exchange diaphragm interposed between two electrodes whereby liquid is transported in an electro-osmotic manner due to an electric field between said electrodes, the improvement wherein said electrodes are hydrogen electrodes connected to each other by way of a line for hydrogen, and wherein said dosing device further includes means for compensating hydrogen losses.

2. An implantable dosing device according to claim 1, wherein said means for compensating hydrogen losses comprises a chamber containing material storing hydrogen under pressure provided at the hydrogen line.

3. An implantable dosing device according to claim 2, wherein said chamber in the hydrogen line contains a transition metal or a transition metal compound storing hydrogen.

4. An implantable dosing device according to claim 3 wherein said transition metal compound is LaCo₅.

5. An implanatable dosing device according to claim 1, wherein said means for compensating hydrogen losses comprises an auxiliary electrode.

6. An implantable dosing device according to claim 5, wherein said auxiliary electrode is a glucose electrode.

7. An implantable dosing device according to claim 5, wherein said auxiliary electrode is a consumable metallic electrode.

8. An implantable dosing device according to claim 1 wherein each of the two hydrogen electrodes is provided with an ion exchange diaphragm on the outside thereof and said liquid chamber is arranged at least in part between the two hydrogen electrodes.

9. An implantable dosing device according to claim 8, wherein the hydrogen electrodes are covered, at least in part, with a layer of asbestos paper on the side facing away from said ion exchange diaphragm.