Device consisting of copolymer having acetoxy groups for delivering drugs
First Claim
1. In a drug delivery device for releasing locally and systemically acting solid, semi-solid and liquid drugs over a prolonged period of time, the device consisting of a drug reservoir containing the drug in an amount for producing a desired physiologic and pharmacologic effect over the time period the device produces therapy, and a polymeric barrier through which the drug passes by diffusion, the improvement wherein said polymeric barrier is a biologically acceptable ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight and a melt index of about 0.1 to 1000 grams per ten minutes, with the drug dissolving in and passing through the ethylene-vinyl acetate copolymer by diffusion at a controlled therapeutically effective rate over the prolonged period of time.
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Abstract
Drug-delivery device for releasing a drug at a continuous and controlled rate for a prolonged period of time is comprised of a shaped body of polymeric material containing a pharmaceutically acceptable drug and permeable to passage of the drug by diffusion. The polymeric material is an ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight and a melt index of about 0.1 to 1000 grams per 10 minutes.
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Citations
6 Claims
- 1. In a drug delivery device for releasing locally and systemically acting solid, semi-solid and liquid drugs over a prolonged period of time, the device consisting of a drug reservoir containing the drug in an amount for producing a desired physiologic and pharmacologic effect over the time period the device produces therapy, and a polymeric barrier through which the drug passes by diffusion, the improvement wherein said polymeric barrier is a biologically acceptable ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight and a melt index of about 0.1 to 1000 grams per ten minutes, with the drug dissolving in and passing through the ethylene-vinyl acetate copolymer by diffusion at a controlled therapeutically effective rate over the prolonged period of time.
Specification