Method and apparatus for gas chromatographic analysis

• US 4,151,741 A
• Filed: 07/11/1977
• Issued: 05/01/1979
• Est. Priority Date: 07/24/1976
• Status: Expired due to Term

• Current Assignee: Bayer AG
• Original Assignee: Bayer AG
• Inventors: Schirrmeister, Horst
• Primary Examiner(s): Kreitman, Stephen A.
• Application Number:
  US05/814,755
• Time in Patent Office: 659 Days
• Field of Search: 73/23.1, 73/27 R, 23/232 C, 23/254 R
• US Class Current: 327/184
• CPC Class Codes: G01N 30/32 of pressure or speed G01N30/36 takes precedence
• CPC Class Codes: G01N 30/66 Thermal conductivity detectors

Abstract

An improvement in the resolution, sensitivity of measurement and sensitivity of detection in gas chromatographic analysis using a capillary column or micropacked column as a separating column and a thermal conductivity cell as a detector wherein the pressure in the gas chamber at the beginning of the separating column is higher than in the detector by a factor of at least 5.

Claims

1. In a method of gas chromatographic analysis wherein the improvement comprises providing a separating column comprising one of a capillary column or micropacked column and a detector comprising a thermal conductivity cell, and maintaining the absolute pressure of the gas immediately upstream of the separating column higher than that in the detector by a factor of at least five by providing a constriction after the separating column and before the detector.

2. A method as claimed in claim 1, further comprising maintaining the pressure of the gas at the outlet of the separating column substantially constant.

3. A method as claimed in claim 2, wherein the pressure of the gas at the outlet of the separating column is substantially atmospheric pressure.

4. A method as claimed in claim 1, further comprising removing gas from the thermal conductivity cell by a vacuum pump and providing a constriction between the vacuum pump and the thermal conductivity cell.

5. A method as claimed in claim 4, wherein an absolute pressure of from 0.5 to 200 mbar is maintained in the thermal conductivity cell by the constrictions arranged before and after the thermal conductivity cell and the pressure at the outlet of the separating column is substantially atmospheric pressure.

6. An apparatus for gas chromatographic analysis, comprising a separating column comprising one of a capillary column or micropacked column, a detector comprising a thermal conductivity cell and means for maintaining the absolute pressure of the gas in the detector lower by a factor of at least five than the absolute pressure of the gas at the outlet of the separating column, comprising a constriction disposed after the separating column and before the detector.

7. An apparatus as claimed in claim 6, further comprising regulating means in communication between the constricton and the separating column to maintain the pressure of the gas at the outlet of the separating column substantially constant.

8. An apparatus as claimed in claim 7, further comprising a vacuum pump connected to the thermal conductivity cell via a further constriction.

9. An apparatus according to claim 7, wherein the regulating means comprises a communication to atmospheric pressure.

10. The apparatus according to claim 7, wherein the regulating means maintains the outlet pressure of the separating column at substantially atmospheric pressure, and comprises a tee-connector disposed between the column and the constriction and having a connection to the atmosphere and wherein the detector maintains a pressure of from 0.5 to 200 mbar.