Collection and separation device

• US 4,152,269 A
• Filed: 02/01/1977
• Issued: 05/01/1979
• Est. Priority Date: 02/01/1977
• Status: Expired due to Term

• Current Assignee: Warner-Lambert Company (Pfizer Inc.)
• Original Assignee: Warner-Lambert Company (Pfizer Inc.)
• Inventors: Babson, Arthur L.
• Primary Examiner(s): Howell, Kyle L.
• Application Number:
  US05/764,505
• Time in Patent Office: 819 Days
• Field of Search: 128/2 F, 128/DIG. 5, 210/83, 210/516, 210/DIG. 23, 210/DIG. 24, 215/247, 215/364, 215/DIG. 8, 206/219, 206/222
• US Class Current: 210/516
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150221 Valves
• CPC Class Codes: A61B 5/150351 Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel caps for bottles or containers in general B65D41/00
• CPC Class Codes: A61B 5/150389 Hollow piercing elements, e.g. canulas, needles, for piercing the skin
• CPC Class Codes: A61B 5/150496 Details of construction of hub, i.e. element used to attach the double-ended needle to a piercing device or sampling device
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/150992 Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings, valves tubing connectors and couplings A61M39/00
• CPC Class Codes: A61B 5/154 Devices using pre-evacuated means
• CPC Class Codes: A61J 1/05 for collecting, storing or administering blood, plasma or medical fluids multiple bags systems for separating or storing blood components A61M1/0209; Infusion or perfusion containers
• CPC Class Codes: A61J 1/1406 Septums, pierceable membranes
• CPC Class Codes: A61J 1/20 Arrangements for transferring or mixing fluids, e.g. from vial to syringe
• CPC Class Codes: G01N 33/491 by separating the blood components G01N15/05 takes precedence
• CPC Class Codes: Y10S 215/08 Mixing

Abstract

A blood collection assembly and closure therefor, for the collection, separation, isolation and storage of serum from blood. The closure is constructed of a cannula penetrable self-sealing elastomer and includes a thixotropic barrier material in a hollow central portion of the closure, so that the barrier material is sealed within the closure until blood has been collected in the collection container and centrifuged. Centrifugation forces the barrier material into a collecton container through the passageway created by the cannula.

Claims

1. An assembly for the collection, separation, isolation and storage of serum from blood which comprises:

a tubular blood collection container (33) having an open end and a closed end;

an elastomeric self-sealing cannula penetrable closure member (10) sealing said open end of the container, said closure member comprising;

a hollow cylindrical body (24) extending into the open end of said container and being surmounted by a coaxial head (23) having a greater diameter than said body, said said head having a flange member (34) seated over the open end of the blood collection container;

an axially extending hollow shaft extending from said head through said body to a point just short of the lower terminus of said body, said lower terminus being of reduced thickness than the remainder of said body and forming a thin cannula penetrable zone;

an elastomeric self-sealing member (12) hermetically closing said hollow shaft at its upper most terminus;

said closed hollow shaft defining a reservoir (21) containing a thixotropic barrier material; and

wherein said assembly is at least partially air evacuated.

2. An elastomeric self-sealing closure comprising a hollow cylindrical body surmounted by a coaxial head portion having a greater diameter than said body, a hollow central shaft extending axially through said body from said head portion to a point just short of the lower terminus of said body wherein the thickness of said body between said lower terminus and the hollow central shaft is less than the thickness between said shaft and the outer surface of said body, whereby there is formed a cannula penetrable bottom portion;

a cannula penetrable seal positioned over the opened end of said hollow shaft in said head portion and sealing said hollow shaft, said sealed hollow shaft defining a reservoir; and

said reservoir containing a sterile thixotropic sealant barrier material.