Chemical analyzer

• US 4,152,390 A
• Filed: 12/02/1977
• Issued: 05/01/1979
• Est. Priority Date: 12/17/1976
• Status: Expired due to Term

• Current Assignee: Clinical Diagnostic Systems Inc.
• Original Assignee: Eastman Kodak Company
• Inventors: Adamski, Henry S., Nosco, Louis C., Di Fulvio, Anthony P.
• Primary Examiner(s): Serwin, R. E.
• Application Number:
  US05/856,834
• Time in Patent Office: 515 Days
• Field of Search: 23/230 R, 23/253 R, 23/259
• US Class Current: 422/63
• CPC Class Codes: G01N 2035/00039 Transport arrangements specific to flat sample substrates, e.g. pusher blade
• CPC Class Codes: G01N 2035/00049 for loading/unloading a carousel
• CPC Class Codes: G01N 2035/00089 Magazines
• CPC Class Codes: G01N 2035/00356 Holding samples at elevated temperature (incubation)
• CPC Class Codes: G01N 35/00029 provided with flat sample substrates, e.g. slides G01N35/028 takes precedence

Abstract

A chemical analyzer is disclosed for performing analysis on selected fluids. The analyzer comprises a plurality of cartridges containing test slides. A slide transfer mechanism is adapted to feed a slide from a selected cartridge, transport the slide to a metering device where a precise amount of fluid is deposited thereon, deliver the slide to conveyor means which moves the element through an incubator, and transport the slide to an analysis means after a predetermined time in the incubator.

Claims

1. Apparatus for measuring a characteristic of a fluid sample wherein the sample is deposited on a test slide which is analyzed after an appropriate period of incubation, said apparatus comprising:

slide supply means;

means adapted to receive a slide from said slide supply means at a metering position where a predetermined quantity of sample is deposited onto the slide;

incubator means adapted to receive a slide bearing said quantity of sample;

analysis means adapted to receive a slide from said incubator means;

means for supporting each of said previously recited means relative to each other to define a path on which slides in contact therewith can be slideably moved through the apparatus; and

slide handling means for moving a slide supported on said path through a plurality of locations on the path.

2. Apparatus, as defined in claim 1, wherein said slide handling means includes an ejector mechanism for removing a slide from said slide supply means and transfer means adapted to receive a slide from said ejector means.

3. Apparatus, as defined in claim 2, wherein said transfer means comprises a forward transfer mechanism for moving a slide from said metering position to a preheater in said incubator means and from said preheater to an incubator rotor, and a rear transfer mechanism for moving a slide from said rotor to said analysis means and from said analysis means to a discharge chute.

4. Apparatus, as defined in claim 3, wherein said ejector mechanism and said transfer mechanisms are driven from a single power source, and each of said mechanisms is selectively engageable with said power source.

5. Apparatus, as defined in claim 4, wherein said ejector mechanism comprises a pusher element, and each of said transfer mechanisms comprises a pair of slide engaging means.

6. Apparatus, as defined in claim 4, wherein said power source is connected to belt drive means, and each of said mechanisms is actuatable through one-revolution clutches adapted to be coupled to said belt drive means.

7. Apparatus, as defined in claim 2, wherein said supply means includes a supply table mounted for pivotable movement, said table having a plurality of chambers for receiving cartridges containing slides, and positioning means is adapted to move said table to locate a selected cartridge such that said ejector mechanism can feed a slide from the cartridge into the metering position.

8. An analyzer for measuring a characteristic of a fluid sample wherein the sample is deposited on a test slide which is analyzed after an appropriate period of incubation, said analyzer comprising:

slide supply means;

metering means adapted to receive and releasably hold a slide from said slide supply means, said metering means being further adapted to deposit a predetermined quantity of sample onto the slide;

incubator means adapted to receive and releasably hold a slide bearing said quantity of sample;

analysis means adapted to receive and releasably hold a slide from said incubator means;

means for supporting each of the previously recited means relative to each other to provide a generally linear slide path whereby slides can be slideably moved through the analyzer along said path; and

slide handling means for sequentially applying a force to a slide supported on said path and in contact therewith to move the slide to a plurality of locations on the path.

9. Slide handling means for use in a chemical analyzer of the type in which a fluid is metered onto a test slide which is analyzed after an appropriate period of incubation, said slide handling means comprising:

a power source;

a plurality of independently actuatable drive means mounted for reciprocation, said drive means being adapted to engage the slide in a predetermined sequence to advance the slide through said analyzer; and

means for selectively engaging each of said drive means with said power source.

10. Slide handling means, as recited in claim 9, wherein said means for selectively engaging each of said drive means comprises clutch means connected to each of said drive means, each of said clutch means being actuated by a solenoid.

11. Slide handling means, as recited in claim 10, wherein said power source comprises a motor adapted to be running continuously during the operation of said analyzer, and belt means transmits power from said motor to said clutch means.

12. Slide handling means, as recited in claim 9, wherein said drive means comprises an ejector mechanism for feeding a slide from a supply cartridge into metering means, a forward transfer mechanism for moving a slide from said metering means to a preheater and from the preheater to an incubator rotor, and a rear transfer mechanism for moving a slide from said incubator rotor to analysis means and from said analysis means to a discharge chute.

13. Slide handling means, as recited in claim 12, wherein each of said transfer mechanisms comprises two pairs of claws, and each pair of claws is adapted to engage and move a slide.

14. Slide handling means, as recited in claim 12, wherein each of said mechanisms includes a slideably mounted element which is adapted to engage and move a slide.

15. Apparatus for chemical analysis of a fluid sample wherein the sample is deposited on a test slide which is analzyed after incubation, including slide supply means, means adapted to receive a slide at a metering position where a predetermined quantity of sample is deposited on the slide, incubator means for receiving a slide bearing said quantity of sample, and analysis means for receiving a slide from the incubator means, the improvement wherein means provides a slide path which extends from said supply means through said metering position and the incubator means to the analysis means, said path being adapted to support a slide in contact therewith, and slide handling means is adapted to slideably move a slide on said path.

16. Apparatus for measuring a characteristic of a fluid sample wherein the sample is deposited on a test slide which is analyzed after an appropriate period of time, said apparatus comprising:

a plurality of apparatus elements, said elements being adapted to interact with the slide in a preselected sequence, said elements including metering means for depositing a predetermined quantity of sample on a slide in a metering position and analysis means for sensing a characteristic of the slide after a predetermined period of time;

means defining a slide path for movement of slides between said elements, said path being adapted to support slides in contact therewith for slidable movement thereon; and

slide handling means for sequentially applying a force to a slide supported on said path to advance the slide past said elements.

17. Apparatus, as defined in claim 16, wherein said path is generally linear and extends through each of said elements.

18. Apparatus, as defined in claim 17, wherein said elements include slide supply means, and said slide handling means includes an ejector mechanism for removing a slide from said slide supply means and transfer means adapted to receive a slide from said ejector means.

19. Apparatus, as defined in claim 18, wherein said elements include incubator means having a preheater and a rotor, said transfer means comprises a forward transfer mechanism for moving a slide from said metering position to said preheater and from said preheater to said rotor, and a rear transfer mechanism for moving a slide from said rotor to said analysis means and from said analysis means to a discharge chute.

20. Apparatus, as defined in claim 16, wherein said slide handling means comprises a plurality of independently actuatable drive means, and means for selectively actuating said drive means.