Zinc and enzyme mouthwash and mouthwash concentrate for reducing dental plaque and calculus formation

• US 4,152,418 A
• Filed: 12/01/1977
• Issued: 05/01/1979
• Est. Priority Date: 04/01/1970
• Status: Expired due to Term

• Current Assignee: CPPD Incorporated
• Original Assignee: Lever Brothers Company (Unilever PLC)
• Inventors: Pader, Morton
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US05/856,469
• Time in Patent Office: 516 Days
• Field of Search: 424/48, 424/58, 424/94
• US Class Current: 424/50
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/66 Enzymes
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

There is disclosed in this specification an improved composition for reducing dental plaque and calculus formation, comprising zinc ions and an organoleptically acceptable enzyme, which may be a protease, carbohydrase, or lipase, or mixtures of these enzymes.

Claims

1. A fluoride-free mouthwash capable or reducing dental plaque and calculus consisting essentially of:

(a) about 0.01% to about 5% of a non-enzyme bound, pharmaceutically acceptable zinc compound selected from the group consisting of zinc acetate, benzoate, borate, carbonate, citrate, dl-lactate trihydrate, phenolsulfonate, silicate, an alkanoate having 8 to 18 carbon atoms, salicylate, stannate, sulfate, tannate and titanate;

(b) about 0.0001% to about 5% of an enzyme preparation selected from the group consisting of a protease, a carbohydrase, a lipase and mixtures thereof;

(c) 0 to about 50% of a non-aqueous liquid selected from the group consisting of ethyl alcohol, propylene glycol, 1,3-butylene glycol and mixtures threof;

(d) 0 to 2% of surfactants and suspending agents; and

(e) the balance water.

2. The mouthwash of claim 1 wherein said zinc salt is zinc phenolsulfonate.

3. The mouthwash of claim 1 wherein said zinc .salt is zinc citrate.

4. The mouthwash of claim 1 wherein said non-aqueous liquid is ethyl alcohol.

5. The mouthwash of claim 1 wherein said enzyme preparation is a protease derived from Bacillus subtilis.

6. The mouthwash of claim 1 wherein said enzyme preparation is a lipase derived from animal pancreas.

7. The mouthwash of claim 1 wherein said enzyme preparation is an amylase.

8. A substantially water-free and fluoride-free fluid suspension for use as a mouthwash concentrate comprising:

(a) about 0.01% to about 15% zinc ions furnished by a non-enzyme bound, pharmaceutically acceptable zinc compound selected from the group consisting of zinc acetate, benzoate, borate, carbonate, citrate, dl-lactate trihydrate, phenolsulfonate, silicate, an alkanoate having 8 to 18 carbon atoms, salicylate, stannate, sulfate, tannate and titanate;

(b) about 0.01% to about 30% of a cosmetically acceptable enzyme preparation selected from the group consisting of protease, a carbohydrase, a lipase and mixtures thereof; and

(c) a non-aqueous liquid base selected from the group consisting of glycerol and ethyl alcohol.

9. The fluid suspension of claim 8 wherein said liquid base is glycerol.

10. The fluid suspension as in claim 8 wherein said zinc compound is zinc phenol sulfonate.

11. The fluid suspension of claim 8 wherein said enzyme preparation is a protease derived from Bacillus subtilis.