Apparatus and method of inserting a microelectrode in body tissue or the like using vibration means

• US 4,154,228 A
• Filed: 08/06/1976
• Issued: 05/15/1979
• Est. Priority Date: 08/06/1976
• Status: Expired due to Term

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Crawford, Donald W., Feldstein, Cyril, Kanabus, Evangelyn W.
• Primary Examiner(s): Truluck, Dalton L.
• Assistant Examiner(s): Thaler, Michael H.
• Application Number:
  US05/712,270
• Time in Patent Office: 1,012 Days
• Field of Search: 128/2 E, 128/2 L, 128/2 M, 128/329 R, 128/2.1 E, 128/2 B, 128/305, 128/303 R, 128/24 A, 128/1 R, 128/173 H, 128/328, 128/355, 30/272 R, 30/272 A, 179/100.4 C, 81/9.22
• US Class Current: 606/169
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/6885 Monitoring or controlling sensor contact pressure
• CPC Class Codes: A61M 25/01 Introducing, guiding, advancing, emplacing or holding catheters A61M25/10 takes precedence

Abstract

An arrangement for and method of inserting a glass microelectrode having a tip in the micron range into body tissue is disclosed. The arrangement includes a microelectrode. The top of the microelectrode is attached to the diaphragm center of a first speaker. The microelectrode tip is brought into contact with the tissue by controlling a micromanipulator. Thereafter, an audio signal is applied to the speaker to cause the microelectrode to vibrate and thereby pierce the tissue surface without breaking the microelectrode tip. Thereafter, the tip is inserted into the tissue to the desired depth by operating the micromanipulator with the microelectrode in a vibratory or non-vibratory state. A mechanism including a second speaker disclosed. Such mechanism is useful to sense tissue motion to control the microelectrode position with respect thereto substantially constant.

Claims

1. In a method of inserting a device in body tissue or the like, the steps comprising:

providing an audio speaker with a vibratory member which vibrates when an audio signal is applied to said speaker;

attaching said device to said vibratory member; and

vibrating said device to pierce the tissue outer surface by applying an audio signal to said speaker.

2. The method as described in claim 1 further including the step of inserting said device into said tissue to a selected depth from said outer surface after said outer surface has been pierced.

3. The method as described in claim 2 wherein said device is vibrated while it is inserted into said tissue.

4. The method as described in claim 1 further including the step of inserting said device into said tissue to a selected depth from said outer surface after said outer surface has been pierced, and wherein said device is vibrated while it is inserted into said tissue.

5. The method as described in claim 1 wherein said body tissue is nonstationary and the method further includes the steps of sensing the motion of said body tissue and controlling the device position with respect to said tissue as a function of the sensed motion of said tissue.

6. The method as described in claim 1 wherein said device is controllably movable toward and away from said tissue with respect to a fixed reference position and said tissue is in a nonstationary state, the method including the steps of sensing changes in the position of said tissue with respect to said reference position and controlling the device position as a function of the changes in the position of said tissue.

7. An arrangement for inserting a device into body tissue or the like comprising:

an elongated device of the type defining a front end adapted to be inserted into body tissue or the like;

support means connected to said device at an end other than said front end, said support means including energizable means comprising a first audio speaker with a vibratory member, which vibrates back and forth along an axis when said speaker is energized by an energizing signal;

mechanical means for mechanically rigidly connecting said vibratory member to said devices, with the front end thereof along said axis, whereby when said vibratory member vibrates along said axis, said front end of said device vibrates therewith along said axis;

energizing means for selectively energizing said speaker; and

positioning means coupled to said support means for controlling the position of said device with the front end thereof with respect to the tissue into which said device is adapted to be inserted, said positioning means include means adapted to sense the motion of said tissue and control means for varying the position of the support means as a function of the sensed tissue motion, said control means comprises a second audio speaker, having a vibratory diaphragm connected to said support means, and a circuit means for applying a signal to said second speaker as a function of the sensed tissue motion so as to cause the diaphragm of said second speaker to move in a direction to thereby control the distance between said support means and said moving tissue substantially constant, when the position of the device with respect to said tissue is not varied by said energizing means.

8. The arrangement as described in claim 7 wherein the centers of the diaphragms of both speakers are aligned along the longitudinal axis of said device with which said device first end is aligned.

9. An arrangement for inserting a device into body tissue or the like, comprising:

an elongated device of the type defining a front end, adapted to be inserted into body tissue or the like;

support means connected to said device at an end other than said front end, said support means including energizable means comprising a vibratory member which vibrates so as to cause said device to vibrate along an axis with which said device'"'"'s front end is aligned, upon the application of an energizing signal to said energizable means;

energizing means for selectively energizing said energizable means; and

positioning means, coupled to said support means, for controlling the position of said device with the front end thereof with respect to the tissue into which said device is to be inserted, said positioning means include means adapted to sense motion of said tissue and control means for varying the position of the support means as a function of the sensed tissue motion, said energizable means comprising a first audio speaker, and said vibratory member is the speaker'"'"'s diaphragm and said energizing means is a source of audio signals for energizing said first speaker, and

said control means comprises a second audio speaker having a vibratory diaphragm connected to said support means, and circuit means for applying a signal to said second speaker as a function of the second tissue motion so as to cause the diaphragm of said second speaker to move in a direction to thereby control the distance between the support means and said moving tissue substantially constant, when the position of the device with respect to said tissue is not varied by said energizing means.

10. The arrangement as described in claim 9 wherein the centers of the diaphragms of both speakers are aligned along the longitudinal axis of said device with which said device first end is aligned.

11. The arrangement as described in claim 10 wherein said device is a microelectrode comprising an elongated tube with a tapered end terminating in a tip defining the device'"'"'s first end.