Zinc and enzyme toothpowder dentifrice

• US 4,154,815 A
• Filed: 12/01/1977
• Issued: 05/15/1979
• Est. Priority Date: 04/01/1970
• Status: Expired due to Term

• Current Assignee: CPPD Incorporated
• Original Assignee: Lever Brothers Company (Unilever PLC)
• Inventors: Pader, Morton
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US05/856,471
• Time in Patent Office: 530 Days
• Field of Search: 424/48-58
• US Class Current: 424/50
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/66 Enzymes
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

There is disclosed in this specification an improved composition for reducing dental plaque and calculus formation, comprising zinc ions and an organoleptically acceptable enzyme, which may be a protease, carbohydrase, or lipase, or mixtures of these enzymes.

Claims

1. A fluoride-free tooth powder capable of reducing dental plaque and calculus consisting essentially of:

(a) about 0.1% to about 30% of a non-enzyme bound, pharmaceutically acceptable zinc acetate, benzoate, borate, carbonate, citrate, dl-lactate trihydrate, phenolsulfonate, silicate, an alkanoate having 8 to 18 carbon atoms, salicylate, stannate, sulfate, tannate or titanate;

(b) from about 0.1% to about 30% of an enzyme preparation selected from the group consisting of a protease, a carbohydrase, a lipase and mixtures thereof; and

(c) about 50% to about 99% dental polishing agent.

2. The tooth powder of claim 1 wherein said zinc compound is zinc phenolsulfonate.

3. The tooth powder of claim 1 wherein said enzyme preparation is a protease derived from Bacillus subtilis.

4. The tooth powder of claim 1 wherein the dental polishing agent is present in an amount of from about 70 to about 95% by weight.

5. The tooth powder of claim 1 wherein the dental polishing agent is present in an amount of from about 90 to about 95% by weight.

6. The tooth powder of claim 1 wherein the dental polishing agent is a silica xerogel.

7. The tooth powder of claim 1 wherein the dental polishing agent is a mixture of silica xerogel and silica aerogel.