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Systems for the controlled release of macromolecules

  • US 4,164,560 A
  • Filed: 01/05/1977
  • Issued: 08/14/1979
  • Est. Priority Date: 01/05/1977
  • Status: Expired due to Term
First Claim
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1. A therapeutic system for the continuous and controlled administration of insulin, said system being in the form of a body which is sized and shaped for placement in the environment of use, comprising a two-phase composition of:

  • (a) a first phase comprising a biocompatible, plastically deformable, hydrophobic matrix having an aqueous fluid sorptivity not greater than 50% by weight, of ethylene-vinyl ester copolymer of the general formula;

    ##STR2## wherein R is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 7 carbons and phenyl, the polymer being insoluble in the environment of use, substantially impermeable to diffusion therethrough of insulin, and containing in admixture therewith;

    (b) a second phase comprising from about 3 to 90 parts by weight of agglomerated particles of insulin.

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