Anti-thrombotic compound and method of making and using the same for pharmaceutical purposes

• US 4,164,585 A
• Filed: 07/01/1976
• Issued: 08/14/1979
• Est. Priority Date: 07/01/1976
• Status: Expired due to Term

• Current Assignee: Cardioquest Corporation
• Original Assignee: Cardioquest Corporation
• Inventors: Sawyer, Philip N., Freeman, Leon D.
• Primary Examiner(s): Fagelson, Anna P.
• Application Number:
  US05/701,874
• Time in Patent Office: 1,139 Days
• Field of Search: 424/280, 424/309, 424/310, 260/343.7
• US Class Current: 514/474
• CPC Class Codes: C07D 307/62 Three oxygen atoms, e.g. ascorbic acid

Abstract

A solution of L-ascorbic acid and a solution of para amino benzoic acid are mixed and the mixture evaporated to permit recovery of a solid compound. The compound is adminstered to a host to reduce thrombotic tendencies.

Claims

1. A method of reducing thrombotic tendencies in a host which comprises administering to the host an amount effective therefor of a compound derived from two organic acids, one of said acids being L-ascorbic acid, the other of said acids being para amino benzoic acid, said compound being:

##STR4##

2. A method as claimed in claim 1 wherein the compound is administered in a dosage of 1-100 mg./kg. of bodyweight.

3. A method as claimed in claim 2 wherein the dosage is administered orally.

4. A method as claimed in claim 1 wherein the compound is administered in a dosage of 1-100 mg./kg. of body weight.

5. A method as claimed in claim 4 comprising using a dosage of 1-20 mg./kg. of bodyweight.

6. A method as claimed in claim 4 wherein the dosage is administered orally.

7. A method as claimed in claim 4 wherein the dosage is administered interperitoneally.