Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines
First Claim
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1. A compound of the formula ##STR14## or a pharmaceutically acceptable acid addition salt thereof in which X is hydrogen, nitro, amino, chlorine, fluorine, bromine or methoxy;
- R is hydrogen, alkyl, alkenyl, hydroxyethyl, alkanoyl, alkoxyoxalyl, unsubstituted or substituted phenylalkanoyl, unsubstituted or substituted benzoyl, unsubstituted or substituted phenylalkyl, cycloalkylalkyl, cycloalkylcarbonyl, furfuryl, furoyl, alkoxycarbonyl, phenoxycarbonyl, unsubstituted or substituted phenoxyalkyl, N-[2-(3-indolyl)ethyl] or (indol-3-yloxalyl) wherein said alkyl, alkenyl, alkanoyl and alkoxy groups have from 1 to 6 carbon atoms, said cycloalkyl groups have from 3 to 7 carbon atoms and the substituents of said substituted groups are selected from nitro, amino, halogen and methoxy; and
n is the integer 1 or 2.
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Abstract
Novel Spiro[dihydrobenzofuran-piperidine and pyrrolidine]s and methods of preparing same are described. These compounds are useful as analgetics and tranquilizers and as intermediates.
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Citations
23 Claims
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1. A compound of the formula ##STR14## or a pharmaceutically acceptable acid addition salt thereof in which X is hydrogen, nitro, amino, chlorine, fluorine, bromine or methoxy;
- R is hydrogen, alkyl, alkenyl, hydroxyethyl, alkanoyl, alkoxyoxalyl, unsubstituted or substituted phenylalkanoyl, unsubstituted or substituted benzoyl, unsubstituted or substituted phenylalkyl, cycloalkylalkyl, cycloalkylcarbonyl, furfuryl, furoyl, alkoxycarbonyl, phenoxycarbonyl, unsubstituted or substituted phenoxyalkyl, N-[2-(3-indolyl)ethyl] or (indol-3-yloxalyl) wherein said alkyl, alkenyl, alkanoyl and alkoxy groups have from 1 to 6 carbon atoms, said cycloalkyl groups have from 3 to 7 carbon atoms and the substituents of said substituted groups are selected from nitro, amino, halogen and methoxy; and
n is the integer 1 or 2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
- R is hydrogen, alkyl, alkenyl, hydroxyethyl, alkanoyl, alkoxyoxalyl, unsubstituted or substituted phenylalkanoyl, unsubstituted or substituted benzoyl, unsubstituted or substituted phenylalkyl, cycloalkylalkyl, cycloalkylcarbonyl, furfuryl, furoyl, alkoxycarbonyl, phenoxycarbonyl, unsubstituted or substituted phenoxyalkyl, N-[2-(3-indolyl)ethyl] or (indol-3-yloxalyl) wherein said alkyl, alkenyl, alkanoyl and alkoxy groups have from 1 to 6 carbon atoms, said cycloalkyl groups have from 3 to 7 carbon atoms and the substituents of said substituted groups are selected from nitro, amino, halogen and methoxy; and
Specification