Method and apparatus for measuring retinal blood flow

• US 4,166,695 A
• Filed: 03/29/1977
• Issued: 09/04/1979
• Est. Priority Date: 04/01/1976
• Status: Expired due to Term

• Current Assignee: National Research Development Corporation
• Original Assignee: National Research Development Corporation
• Inventors: Hill, David W., Pike, Edward R.
• Primary Examiner(s): Buczinski, S. C.
• Application Number:
  US05/782,510
• Time in Patent Office: 889 Days
• Field of Search: 356/103, 356/39, 356/28, 351/6, 351/7, 351/16, 128/2 T, 128/2.05 F
• US Class Current: 356/28
• CPC Class Codes: A61B 3/1233 for measuring blood flow, e.g. at the retina
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: G01F 1/661 using light

Abstract

Blood flow in retinal blood vessels is measured by directing laser radiation along an optical path into the eye and onto a blood vessel. Laser radiation reflected off moving blood corpuscles is directed back along the optical path and into a detector. This reflected laser radiation is mixed with a proportion of the original laser signal to determine the doppler shift produced by the moving blood corpuscles and hence blood velocity.

Claims

1. Apparatus for measuring retinal blood flow comprising a laser for producing a beam of radiation, means for directing a single beam of the laser radiation along an optical path into an eye and onto a retinal blood vessel, a detector for detecting laser radiation reflected from blood corpuscles within the blood vessel, and for producing a doppler output signal, means for directing laser radiation reflected by the eye into the detector, means for variably deflecting the laser radiation across the optical path to enable the desired part of the retinal blood vessels to be illuminated by the laser radiation and defining an acceptance angle, a light source for general illumination of the fundus of the eye, means for observing light and laser radiation reflected by the eye and for determining the angle of the blood vessel, the doppler angle of the blood vessel being determined from said acceptance angle and said angle of the blood vessel, whereby the laser radiation may be directed along the optical path and onto the retinal blood vessel and the laser radiation reflected from the blood vessel is reflected back along the optical path into the detector to determine the doppler shift of laser radiation and hence blood flow velocity from the value of the doppler output signal and from the doppler angle defined by said acceptance angle and said angle of blood vessel.

2. Apparatus according to claim 1 and comprising a beam splitter for directing a proportion of the laser radiation onto a reflector and thence back into the detector to form a signal for mixing with radiation scattered by the retinal blood vessel.

3. Apparatus according to claim 2 wherein means are provided for varying the amount of signal that is reflected back into the detector.

4. Apparatus according to claim 1 wherein the means for directing radiation into the detector includes a polarising prism which transmits one plane of polarisation and reflects an orthogonal plane of polarisation.

5. Apparatus according to claim 4 wherein the means for directing radiation into the detector comprises a quarter wave plate for changing the plane of polarisation reflected back along the optical path.

6. Apparatus according to claim 1 wherein the means for variably deflecting laser radiation comprises a plate of transparent material whose surfaces are adjustable about a plane normal to the optical path.

7. Apparatus according to claim 1 and comprising an adjustable target and reflecting surfaces for reflecting an image of the target into the eye whereby the eye can be positioned with the optic axis along the optical path of the apparatus.

8. Apparatus according to claim 7 wherein the means for observing radiation reflected by the eye includes a beam splitter for reflecting a part of light reflected by the eye through a viewing eye piece means.