Device for administering solid drug particles to an eye

• US 4,173,226 A
• Filed: 07/07/1978
• Issued: 11/06/1979
• Est. Priority Date: 11/10/1977
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Shell, John W.
• Primary Examiner(s): Yasko, John D.
• Application Number:
  US05/922,742
• Time in Patent Office: 487 Days
• Field of Search: 128/233, 128/232, 128/231, 128/216, 128/272.1, 128/260, 206/221, 206/219
• US Class Current: 604/295
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts

Abstract

An ophthalmic bioerodible dosage form for ophthalmic drugs is disclosed. The dosage form comprises particles of 10 to 300 microns made of drug dispersed within a drug release rate controlling material which bioerodes in the environment of the eye.

Claims

1. A container made in the shape of a single dosage dropper adapted for administering drug to an eye, said container consisting essentially of;

a wall defining the container, said wall made of a member selected from the group consisting of a plastic and a glass, and terminated in;

a tip with the wall thereof surrounding and forming a hole;

a cover for the tip;

a space in the container;

a barrier in the space;

a valve carried by the barrier; and

an upper and a lower chamber in the space formed by the barrier, said upper chamber containing solid drug particles administered by the dropper through the hole to the eye, and the lower chamber containing a physiological acceptable carrier for the particles which carrier can move through the valve into the upper chamber and mix with the particles therein.

2. A container made in the shape of a dosage dropper adapted for administering drug to an eye according to claim 1, wherein the carrier is a member selected from the group consisting of a physiologically acceptable oil, water and saline.

3. A container made in the shape of a dosage dropper adapted for administering drug to an eye according to claim 1, wherein a member selected from the group consisting essentially of methyl cellulose and poly(vinyl alcohol) is mixed with the carrier.