Apparatus and process for antifact rejection through cross correlation in sphygmometry

• US 4,174,707 A
• Filed: 12/27/1976
• Issued: 11/20/1979
• Est. Priority Date: 12/27/1976
• Status: Expired due to Term

• Current Assignee: Baxter International Inc.
• Original Assignee: American Optical Corporation
• Inventors: Link, William T., Haney, Jerry D., Jansen, William D.
• Primary Examiner(s): Michell, Robert W.
• Assistant Examiner(s): Jaworski, Francis J.
• Application Number:
  US05/754,200
• Time in Patent Office: 1,058 Days
• Field of Search: 128/2.05 A, 128/2.05 C, 128/2.05 D, 128/2.05 E, 128/2.05 G, 128/2.05 M, 128/2.05 Z, 128/2.05 Q
• US Class Current: 600/494
• CPC Class Codes: A61B 5/02208 using the Korotkoff method
• CPC Class Codes: A61B 5/02225 using the oscillometric method
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

In a system for measuring blood pressure and the like based on a sensed quantity representing the sum of pressure applied by a pressure cuff and a fluctuating component representative of the pulsatile pressure within the blood vessel method and apparatus for indicating blood pressure only if that pressure determined in a first preferred manner correlates substantially with a pressure determined in a secondary, different manner. More specifically, the sensed quantity is analyzed in a manner preferred for determining diastolic pressure and a manner preferred for determining systolic pressure, and the diastolic and systolic pressures or pressure ranges established by analyzing the sensed quantity in a secondary manner or manners. Examples of preferred and secondary techniques for diastolic and systolic pressure determinations are discussed.

Claims

1. An apparatus for producing information indicative of the physical condition of a living test subject comprising:

means for applying a selectively changeable pressure to the test subject adjacent a blood vessel and means for measuring a fluctuating quantity proportional to a sum, said sum comprising a time dependent fluctuating component representative of the pulsatile pressure within the blood vessel, plus the selectively changeable pressure applied externally adjacent the blood vessel;

first means responsive to said quantity in a first analytical manner for providing at least one primary signal tentatively representative of the changeable pressure applied to the living test subject;

second means responsive to said quantity in a second analytical manner different from said first analytical manner for defining at least one respective zone-of-acceptance expressed in terms of a corresponding representation of said changeable applied pressure; and

means for comparing a said primary signal with a respective said zone of acceptance and producing an output of said primary signal as being representative of the physical condition of the living test subject only if said primary signal is within said respective zone-of-acceptance.

2. The apparatus of claim 1 wherein said zone-of-acceptance defining means comprises means for determining a reference value in said second analytical manner and means responsive to said reference value for defining a zone-of-acceptance having a predetermined relationship to said reference value.

3. The apparatus of claim 2 wherein a said zone-of-acceptance is of greater breadth than the respective said primary signal.

4. The apparatus of claim 1 wherein said primary signal is representative of at least one of the diastolic and systolic pressures of the blood vessel.

5. The apparatus of claim 4 wherein said first analytical means provide two primary signals, said two primary signals being tentatively representative of the diastolic pressure and the systolic pressure respectively of the blood vessel and said zone-of-acceptance defining means defining two different zones-of-acceptance, one said zone-of-acceptance being for the determination of a diastolic pressure and the other said zone-of-acceptance being for the determination of a systolic pressure, and wherein said primary tentative diastolic and systolic signals are compared with said diastolic and systolic zones-of-acceptance respectively thereby to produce an output of the respective primary signal only if it is within the respective zone-of-acceptance.

6. The apparatus of claim 5 additionally including means responsive to either of said primary diastolic and systolic signals being outside its respective zone-of-acceptance for preventing output of either said primary diastolic and systolic signals.

7. The apparatus of claim 6 additionally including means responsive to either of said primary diastolic and systolic signals being outside its respective zone-of-acceptance for outputting an error indication.

8. The apparatus of claim 1 additionally including means responsive to said quantity in a third analytical manner different from said first and second analytical manners for defining at least one other zone-of-acceptance expressed in terms of said test subject physical condition, and means for comparing a said primary signal with a respective said other zone-of-acceptance and outputting said primary signal only if it is within at least one of said respective zone-of-acceptance and said respective other zone-of-acceptance.

9. The apparatus of claim 8 wherein a said primary signal is outputed only if it is within both said respective zone-of-acceptance and said respective other zone-of-acceptance.

10. The apparatus of claim 1 wherein said primary signal providing means includes means for converting said quantity into a representation of the first time derivative thereof;

means for substantially maximizing said first negative time derivative of at least the fluctuating component of the quantity as a function of the applied pressure at a measurement time within the pulse, the particular applied pressure which corresponds with said maximized first time derivative comprising the diastolic pressure of the blood vessel, said particular applied pressure being said primary signal.

11. In apparatus for producing information indicative of the physical condition of a living test subject said apparatus including means for applying a selectively changeable pressure to the test subject adjacent a blood vessel and means for measuring a fluctuating quantity proportional to a sum, said sum comprising a time dependent fluctuating component representative of the pulsatile pressure within the blood vessel, plus the selectively changeable pressure applied externally adjacent the blood vessel, the improvement comprising

first means responsive to said quantity in a first analytical manner for providing at least one primary signal tentatively representative of the changeable pressure applied to the living test subject;

second means responsive to said quantity in a second analytical manner different from said first analytical manner for defining at least one respective zone-of-acceptance expressed in terms of a corresponding representation of said changeable applied pressure; and

means for comparing a said primary signal with a respective said zone-of-acceptance and producing an output of said primary signal as being representative of the physical condition of the living test subject only if said primary signal is within said respective zone-of-acceptance.

12. A process for producing information indicative of the physical condition of a living test subject comprising applying a selectively changeable pressure to the test subject externally adjacent a blood vessel and measuring a quantity proportional to a sum, said sum comprising a time dependent fluctuating component representative of the pulsatile pressure within the blood vessel, plus the changeable pressure applied externally adjacent the blood vessel;

analyzing said quantity in a first manner to provide at least one primary signal tentatively representative of changeable pressure applied to a living test subject;

analyzing said quantity in a second manner different from said first analytical manner to define at least one respective zone-of-acceptance expressed in terms of a corresponding representation of said changeable applied pressure; and

comparing a said primary signal with a respective said zone-of-acceptance and providing an output of said primary signal as being representative of the physical condition of a living test subject only if said primary signal is within said respective zone-of-acceptance.

13. The process of claim 12 wherein said step of defining said zone-of-acceptance comprises determining a reference value in said second analytical manner and defining a said zone-of-acceptance having a predetermined relationship to said reference value.

14. The method of claim 13 wherein a said zone-of-acceptance is of greater breadth than the respective said primary signal.

15. The method of claim 12 wherein said primary signal is representative of at least one of the diastolic and systolic pressures of the blood vessel.

16. The method of claim 15 wherein said first analyzing of said quantity provides two primary signals, said two primary signals being tentatively representative of the diastolic and the systolic pressure respectively of the blood vessel and said second analyzing of said quantity defines two different zones-of-acceptance, one said zone-of-acceptance being for the determination of a diastolic pressure and the other said zone-of-acceptance being for the determination of a systolic pressure, and comparing said primary tentative diastolic and systolic signals with said diastolic and systolic zones-of-acceptance respectively thereby producing an output of the respective primary signal only if it is within the respective zone-of-acceptance.

17. The method of claim 16 additionally including the step of preventing output of either of said primary diastolic and systolic signals if either of the respective primary diastolic and systolic signals is outside its respective zone-of-acceptance.

18. The method of claim 17 including the additional step of outputting an error indication if either of said primary diastolic and systolic signals is outside its respective zone-of-acceptance.

19. The method of claim 12 additionally including the step of analyzing said quantity in a third manner different than said first and second analytical manners to define at least one other zone-of-acceptance expressed in terms of said test subject physical condition, and comparing a said primary signal with a respective said other zone-of-acceptance and outputting said primary signal only if it is within at least one of said respective zone-of-acceptance and said respective other zone-of-acceptance.

20. The method of claim 19 including outputting a said primary signal only if it is within both said respective zone-of-acceptance and said respective other zone-of-acceptance.

21. The method of claim 12 wherein said analyzing in said first manner comprises converting said quantity into a representation of the first time derivative thereof, substantially maximizing said first time derivative of at least the fluctuating component of the quantity as a function of the applied pressure at a measurement time within the pulse, and providing the applied pressure which corresponds with said maximized first time derivative as said primary signal, said primary signal comprising the diastolic pressure of the blood vessel.

22. In a process for producing information indicative of the physical condition of a living test subject including applying a selectively changeable pressure to the test subject externally adjacent a blood vessel and measuring a quantity proportional to a sum, said sum comprising a time dependent fluctuating component representative of the pulsatile pressure within the blood vessel, plus the changeable pressure applied externally adjacent the blood vessel, the improvement comprising:

analyzing said quantity in a first manner to provide at least one primary signal tentatively representative of a changeable pressure applied to a living test subject;

analyzing said quantity in a second manner different from said first analytical manner to define at least one respective zone-of-acceptance expressed in terms of a corresponding representation of said changeable applied pressure; and

comparing a said primary signal with a respective said zone-of-acceptance and providing an output of said primary signal as being representative of the physical condition of a living test subject only if said primary signal is within said respective zone-of-acceptance.