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Dual resolution method and apparatus for use in automated classification of pap smear and other samples

  • US 4,175,860 A
  • Filed: 05/31/1977
  • Issued: 11/27/1979
  • Est. Priority Date: 05/31/1977
  • Status: Expired due to Term
First Claim
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1. A method of analyzing and automatically classifying a large number of cells in a field on a support, comprising the steps of:

  • prescreening the field of cells and designating the locations of objects in the field as subject cells for closer examination, bringing the subject cells into a position for a detailed analysis at a low resolution of the entire cell and at a higher resolution of an internal or nuclear portion of the cell,producing a large field of view image at high resolution including a high resolution image of the entire cell, demagnifying the large field of view image to produce a low resolution image of said entire cell with sufficient detail to extract features relating to the total cell,using only an internal portion of said large field of view to produce a high resolution image of substantially only the internal or nuclear portion of said subject cell and excluding substantially the remainder of the cell,simultaneously performing measurements and analysis on said low resolution image of the entire cell and on the internal or nuclear portion high resolution image including the extracting of features relating to texture of its internal or nuclear portion,and classifying the cells in the field based on the features extracted simultaneously from said different images having said different resolutions.

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