Biocompatible articles having high permeability to gases derived from polysulfones

• US 4,179,757 A
• Filed: 05/10/1976
• Issued: 12/25/1979
• Est. Priority Date: 02/22/1972
• Status: Expired due to Term

• Current Assignee: Owens-Illinois Pty Limited (O-I Glass, Inc.)
• Original Assignee: Owens-Illinois Incorporated (O-I Glass, Inc.)
• Inventors: Gray, Don N., Crawford, James E.
• Primary Examiner(s): Henderson, C. A.
• Application Number:
  US05/684,683
• Time in Patent Office: 1,324 Days
• Field of Search: 3/1, 3/1.4, 3/1.5, 128/156, 128/348, 210/500 M, 351/160
• US Class Current: 623/1.49
• CPC Class Codes: A61F 13/01008 characterised by the material
• CPC Class Codes: A61F 2/2421 with non-pivoting rigid closure members
• CPC Class Codes: A61F 2013/00217 not adhering to the wound with wax A61F2013/00161
• CPC Class Codes: A61F 2013/15048 for protection against contamination, or protection in using body disinfecting wipes
• CPC Class Codes: A61L 15/26 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: A61L 2/00 Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for contact lenses A61L12/00; atomisers for disinfecting agents A61M; sterilisation of packages or package contents in association with packaging B65B55/00; treatment of water, waste water, sewage or sludge C02F; disinfecting paper D21H21/36; disinfecting devices for water closets E03D; articles having provision for disinfection, see the relevant subclasses for these articles, e.g. H04R1/12
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 33/068 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L33/062 takes precedence
• CPC Class Codes: B01D 69/02 characterised by their properties
• CPC Class Codes: B01D 71/68 Polysulfones; Polyethersulfones
• CPC Class Codes: C08G 75/22 Copolymers of sulfur dioxide with unsaturated aliphatic compounds
• CPC Class Codes: C08L 81/00 Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing sulfur with or without nitrogen, oxygen or carbon only; Compositions of polysulfones; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 81/06 Polysulfones; Polyethersulfones

Abstract

There is disclosed the preparation of an alpha-olefin-sulfur dioxide copolymer derived from the C₈ to C₁₈ alpha-olefins. The polymers undergo clean thermal degradation, having high permeabilities to oxygen and carbon dioxide, and are readily processed into a membrane article. Maximum permeabilities are obtained with the C₁₆ based polymer. New uses of the copolymer are set forth including perfusion membranes, soft contact lenses and biocompatible articles for contact with human body fluids including surgical tubing, wound dressings, and prosthetic devices such as artificial veins, arteries and heart valves.

Claims

1. The new use of a polysulfone polymer, the new use comprising the steps of:

(1) making an article adapted for biomedical surgical implantations of a highly-processable copolymer that is the reaction product of;

(a) an alpha-olefin having about 16 to 18 carbon atoms; and

(b) sulfur dioxide; and

(2) implanting the article of step (1) in a human body as a surgical implant,

said implanted article characterized by its biocompatibility with human blood.

2. The new use of a polysulfone polymer, the new use comprising the steps of:

(1) making a permselective membrane article adapted for biomedical usage with human blood of a copolymer of;

(a) an alpha-olefin having 16 to 18 carbon atoms; and

(b) sulfur dioxide; and

(2) oxygenating human blood using the membrane article of step (1),

said membrane article characterized by its biocompatibility with human blood and its high permeability.

3. The new use of a polysulfone polymer, the new use comprising the steps of:

(1) making a permselective membrane article adapted for biomedical usage of a copolymer of;

(a) an alpha-olefin having 16 to 18 carbon atoms; and

(b) sulfur dioxide; and

(2) separating components of gases in biomedical procedures using the permselective membrane of step (1), said permselective membrane article characterized by its biocompatibility with human blood.

4. The new use of a polysulfone polymer, the new use comprising the steps of:

(1) making a prosthetic article adapted for biomedical usage of a copolymer of;

(a) an alpha-olefin having 16 to 18 carbon atoms and

(b) sulfur dioxide; and

(2) using the prosthetic article of step (1) as biomedical surgical tubing to transport blood to and from a human body,

said prosthetic article characterized by its biocompatibility with said blood.

5. The new use of a polysulfone polymer, the new use comprising the steps of:

(1) making a biomedical article adapted for contact with human blood, the article being made of a copolymer of

(a) an alpha-olefin having 16 to 18 carbon atoms and

(b) sulfur dioxide; and

(2) contacting human blood with the article of step (1), said article characterized by its biocompatibility and nonthrombogenic properties and its good oxygen and carbon dioxide permeabilities.

6. An article of manufacture for use in contact with human blood and characterized by its biocompatibility therewith, surgical tubing formed of a polysulfone copolymer that is a reaction product of:

A. An alpha-olefin having 16 to 18 carbon atoms, and

B. sulfur dioxide.

7. An article of manufacture, a wound dressing for use in contact with the human body and in contact with human blood and characterized by its biocompatibility therewith, said article made of polysulfone copolymer that is a reaction product of:

(1) an alpha-olefin having 16 to 18 carbon atoms, and

(2) sulfur dioxide,

said copolymer having an oxygen transmission rate of about 1 to 4×

10^-4 CC MIL/IN² YR. ATM.

8. An article of manufacture, an artificial artery for use biomedically with the human body and in contact with human blood and characterized by its biocompatibility therewith, said article made of a polysulfone copolymer that is a reaction product of:

(1) an alpha-olefin having 16 to 18 carbon atoms, and

(2) sulfur dioxide,

said artificial artery having a combination of additional properties making it useful in biomedical applications including good tensile strength, good elongation, and non-thrombogenicity.

9. An article of manufacture, an artificial vein for use biomedically with the human body and in contact with human blood and characterized by its biocompatibility therewith, said article made of a polysulfone copolymer that is a reaction product of:

(1) an alpha-olefin having 16 to 18 carbon atoms, and

(2) sulfur dioxide,

said vein having a combination of additional properties making it useful in biomedical applications, including good tensile strength, good elongation, and non-thrombogenicity.

10. An article of manufacture, a heart valve for use biomedically with the human heart and in contact with human blood and characterized by its biocompatibility therewith, said article made of a copolymer that is a reaction product of:

(1) an alpha-olefin having 16 to 18 carbon atoms and

(2) sulfur dioxide,

said heart valve having a combination of additional properties making it useful in biomedical applications, including good tensile strength, good elongation, and non-thrombogenicity.

11. An article of manufacture, a surgical implant for use biomedically in the human body and in contact with human blood and characterized by its biocompatibility therewith, said article made of a polysulfone copolymer that is a reaction product of:

(1) an alpha-olefin having 16 to 18 carbon atoms, and

(2) sulfur dioxide,

said surgical implant having a combination of additional properties making it useful in biomedical applications, including good tensile strength and elongation, non-thrombogenicity, oxygen transmission rate of about 1 to 4×

10^-4 CC MIL./IN² YR ATM. and a CO₂ transmission rate of about 4 to 17×

10^-4 CC MIL./IN² YR ATM.