Chemical-sensitive field-effect transistor

• US 4,180,771 A
• Filed: 12/02/1977
• Issued: 12/25/1979
• Est. Priority Date: 12/02/1977
• Status: Expired due to Term

• Current Assignee: Airco, Inc. (Linde Plc)
• Original Assignee: Airco, Inc. (Linde Plc)
• Inventors: Guckel, Henry
• Primary Examiner(s): Rolinec, Rudolph V.
• Assistant Examiner(s): Snow, Walter E.
• Application Number:
  US05/856,935
• Time in Patent Office: 753 Days
• Field of Search: 357/23, 357/25, 324/71 SN, 324/29, 324/30 R, 128/2 E, 128/2.1 E, 204/195 M, 204/195 P, 204/195 G, 27/571
• US Class Current: 324/71.1
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: G01N 27/414 Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

Abstract

The invention relates to an insulated-gate field effect transistor which is adapted for detecting and measuring various chemical properties such as ion activity in a solution. The device has a chemically sensitive layer which overlies a portion of a substrate other than that covered by the gate insulator. When this chemically sensitive layer is exposed to a solution or other substance, the electric field in the substrate is modified which changes the conductance of the channel between a source region and a drain region. The change in conductance is related to the chemical exposure and can be detected with a current meter.

Claims

1. A field-effect transistor device for measuring a chemical property of a substance to which the device is exposed, comprising:

a semiconductor substrate;

a source region in contact with the substrate and located near a first surface of the substrate;

a drain region in contact with the substrate, located near the first surface of the substrate and spaced apart from the source region;

a gate insulator which overlies a first area of the first surface of the substrate between the source and drain regions;

three electrodes for providing a separate electrical connection to the source region, drain region, and gate insulator; and

a layer of chemically sensitive material which overlies a second area of the substrate separate from the first area and which has an active surface for exposure to the substance, said chemically sensitive material connected in series with the substrate and located on the opposite side of the substrate from the gate insulator, said second area located sufficiently near the source and drain regions so that exposure of the chemically sensitive material to the substance results in a change of the electrical conductance between the source and drain regions.

2. The device of claim 1 in which the chemically sensitive material lies on the substrate directly opposite the gate insulator.

3. The device of claim 2 further comprising an encapsulating layer of a material which is impervious to the test substance and which has an opening to allow exposure of the active surface.

4. The device of claim 2 further comprising:

a reference electrode attached to the device on the same side of the substrate as the chemically sensitive material and having a surface for exposure to the substance; and

a contact for making an electrical connection to the reference electrode.

5. The device of claim 2 wherein the chemically sensitive material is a membrane which interacts with a particular kind of ion when exposed to a solution containing such ions.

6. The device of claim 5 wherein the membrane is a pH sensitive glass.

7. The device of claim 5 wherein the membrane is a polymeric material containing an ion-exchanger.

8. The device of claim 1 comprising a probe for insertion into the human body.

9. The device of claim 4 comprising an instrument for measuring a medically significant chemical property in a human body, and further comprising:

an electric circuit which includes

a potential source and a current meter connected in series with the source electrode and the drain electrode, and

an electrical connection between the contact of the reference electrode and the gate electrode.

10. The device of claim 1 wherein the three electrodes are all on the same side of the substrate and the chemically sensitive material is on the opposite side of the substrate from that of the three electrodes.