Blood leak detector suitable for use with artificial kidneys

• US 4,181,610 A
• Filed: 07/08/1976
• Issued: 01/01/1980
• Est. Priority Date: 07/14/1975
• Status: Expired due to Term

• Current Assignee: Takeda Chemical Industries, Ltd. (Takeda Pharmaceutical Company Limited)
• Original Assignee: Takeda Chemical Industries, Ltd. (Takeda Pharmaceutical Company Limited)
• Inventors: Nishikawa, Masao, Shintani, Motoaki, Wada, Yoshikazu, Ouchida, Akira, Nakamachi, Hideo
• Primary Examiner(s): Spear, Jr., Frank A.
• Application Number:
  US05/703,628
• Time in Patent Office: 1,272 Days
• Field of Search: 128/214 E, 128/2 L, 128/2 G, 128/DIG. 3, 128/DIG. 13, 128/2 R, 356/40, 356/41, 356/189, 356/181, 356/51, 356/246, 356/39, 210/96 M, 210/34 B, 210/85, 210/87, 200/227, 300/96 B, 300/96 C
• US Class Current: 210/85
• CPC Class Codes: A61M 1/1692 Detection of blood traces in dialysate
• CPC Class Codes: A61M 2205/3313 used specific wavelengths
• CPC Class Codes: G01N 21/314 with comparison of measurements at specific and non-specific wavelengths dual wavelength spectrometry G01J3/427
• CPC Class Codes: G01N 21/85 Investigating moving fluids or granular solids

Abstract

A high sensitive and stable blood leak detector suitable for use with artificial kidneys. The detector has an optical portion comprising a measurement cell through which dialysis solution under test passes, an alternately energized pair of light-emitting diodes positioned on one side of the cell, and a photo sensitive detector positioned at the opposite side of the cell and close thereto. One light-emitting diode emits radiation at longer wavelengths, and the other at shorter wavelengths. Both the diodes are adjusted to produce photo detecting signals at the same level when no blood exists in the cell. The photo detecting signals at the photosensitive detector are detected and analyzed to give signals deflected in one direction in proportion to the degree of blood leak when it has occurred. When bubbles are detected, they give signals in the opposite direction, based on the fact that blood absorbs light mainly at shorter wavelengths while bubbles scatter light mainly at longer wavelengths.

Claims

1. Blood leak detector which comprises:

a tubular measurement cell having at least a central part thereof which is transparent and having an inlet at one end thereof for a dialysis solution under test and an outlet at the other end thereof;

light-emitting means for irradiating said measurement cell, comprising a first light-emitting element emitting mainly at wavelengths of 500-600 nm at which blood pigment absorbs light and a second light-emitting element emitting mainly at longer wavelengths than said first light-emitting element at wavelengths of 600 to 750 nm;

photo detecting means for receiving the light transmitted through said measurement cell;

means for alternately driving said first light-emitting element and the second light-emitting element and,

means for discriminating among output signals of said photo detecting means, said driving means supplying a reference signal to said discriminating means for enabling thereof to discriminate between a first state wherein the amount of the transmitted light of said first light-emitting element is in equilibrium with that of said second light-emitting element, and a second state wherein the amount of the transmitted light of said first light-emitting element is smaller than that of said second light-emitting element.

2. Blood leak detector according to claim 1 which comprises:

AC amplifying means to amplify an AC component of a photo detecting signal of photo detecting means; and

phase discriminating means which is supplied with an emission switching signal as a reference input signal and with an output signal of the AC amplifying means as an input signal to be detected.

3. Blood leak detector according to claim 1 wherein a photo detecting area of photo detecting means has dimensions smaller than the length traverse to said measurement cell.

4. Blood leak detector according to claim 1 wherein said means for alternately driving said first light-emitting element and said second light-emitting element comprises:

sealed constant voltage integrated circuit means having a constant output terminal and a power input terminal voltage;

switching means having an input control line and a 2-terminal switching circuit which is cycled on and off by said input control line;

circuit means to connect one of said lines of said switching circuit to a power line;

circuit means to provide a square wave signal in the range of 100 Hz to 100 KHz to said input control line of said switching means;

circuit means to connect the other line of said switching circuit to said constant voltage integrated circuit means; and

,

circuit means to connect either said first light-emitting element or said second light-emitting element to said constant voltage integrated circuit means.

5. Blood leak detector according to claim 1 wherein said measurement cell has a tapered portion to reduce the cross-section thereof between said inlet for dialysis solution and a light path crossing said measurement cell.

6. Blood leak detector according to claim 1 which additionally comprises:

push button switch means connected to circuit means permitting either to reduce luminous intensity of a first light-emitting diode or to increase luminous intensity of a second light-emitting diode and causing unbalance electrically between photo detector outputs; and

a sensitivity checking system indicating a predetermined level of blood leak by operating the push button switch means without using reference samples.

7. Blood leak detector according to claim 1 which additionally comprises:

alarm means to provide an audibly distinguishable warning responsive to at least one of the factors of frequency, amplitude and intermission, which varies in accordance with the strength of a blood leak output signal.

8. Artificial kidney dialysis system which comprises:

a blood leak detector according to claim 1, a first tube to introduce blood before dialysis into a dialyzer;

a second tube to introduce blood after dialysis into a blood vessel;

a third tube connected to a blood inlet of the dialyzer;

a fourth tube connected to a blood outlet of the dialyzer;

flow path means capable of being switched over between a first state in which the first tube is interconnected to the third tube and the second tube is interconnected to the fourth tube, and a second state in which the first tube in interconnected to the second tube; and

state switching over means to switch over the flow path means from the first state to the second state on detecting the output signal of the blood leak detector, whereby when a blood leak signal is produced, the first tube, to introduce blood before dialysis into the dialyzer, is interconnected to the second tube to introduce blood after dialysis into the blood vessel, to prevent the blood from entering the dialyzer.

9. Blood leak detector which comprises:

a transparent measurement cell through which dialysis solution under test flows;

composite light-emitting diodes irradiating the measurement cell and having a first light-emitting diode which emits in the range of 520-600 nm and a second light-emitting diode which emits in the range of 600-750 nm;

a photo detecting element to receive the light from the light emitting diodes transmitted through the measurement cell;

means for driving the first light-emitting diode and the second light-emitting diode alternatively after a reference square wave signal;

means for adjusting the balance between an output signal of a photo detecting element due to the first light-emitting diode and an output signal of the photo detecting element due to the second light-emitting diode in the normal state in which no blood leak exists; and

means for detecting deflection from the normal state resulting from change either of the output signal of the photo detecting element due to the first light-emitting diode or of the output signal of the photodetecting element due to the second light-emitting diode.

10. Blood leak detector according to claim 9 wherein said reference square wave signal is used to cause a difference in the duration of the emitting time between said first and said second light-emitting diode.

11. Blood leak detector according to claim 9 which additionally comprises:

a first driving circuit and a second driving circuit for energizing alternately a first light-emitting diode and a second light-emitting diode; and

a thermal sensitive element connected either to the first driving circuit or to the second driving circuit and positioned in proximity to the diodes so as to compensate automatically the change of the intensities of the first light-emitting diode and the second light-emitting diode due to temperature change.