Membrane unit and device for cleansing blood

• US 4,183,811 A
• Filed: 09/01/1977
• Issued: 01/15/1980
• Est. Priority Date: 09/02/1976
• Status: Expired due to Term

• Current Assignee: Hoechst Aktiengesellschaft (Sanofi )
• Original Assignee: Hoechst Aktiengesellschaft (Sanofi )
• Inventors: Walch, Axel, Lammers, Ludwig
• Primary Examiner(s): Hart, Charles N.
• Assistant Examiner(s): Lander, Ferris H.
• Application Number:
  US05/829,941
• Time in Patent Office: 866 Days
• Field of Search: 210/321, 210/493, 210/494, 210/500 M, 210/502, 210/22, 210/23
• US Class Current: 210/646
• CPC Class Codes: A61M 1/3472 with treatment of the filtrate
• CPC Class Codes: A61M 1/3489 by biological cells, e.g. bioreactor
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: B01D 15/00 Separating processes involving the treatment of liquids with solid sorbents using liquid sorbents B01D11/00; ion exchange processes or materials, sorbent materials in general B01J, e.g. sorbents for chromatography B01J20/281; for investigating or analysing materials G01N30/00; Apparatus therefor
• CPC Class Codes: B01D 61/28 Apparatus therefor
• CPC Class Codes: B01D 63/10 Spiral-wound membrane modules
• CPC Class Codes: B01D 63/101 Spiral winding

Abstract

A membrane unit and apparatus for removing toxic metabolites and metabolites normally present in urine from blood is disclosed. The unit comprises a cavity through which the contaminated blood passes, said cavity comprising at least one permselective membrane and at least one adsorbent. The apparatus comprises at least one membrane unit which is connected to inlet and outlet means for transporting contaminated blood to the unit and decontaminated blood from the unit.

Claims

1. A membrane unit for simultaneously removing toxic metabolites and metabolites normally present in urine from blood, comprising at least one cavity through which the contaminated blood passes, said cavity being defined by a first wall comprised of a permselective membrane having a pore size adapted to selectively remove from the blood metabolites normally present in urine, including water, electrolytes, urea and ammonia, and a second wall spaced from said first wall and comprising at least one adsorbant for removing toxic metabolites from the blood, whereby the blood simultaneously directly contacts both said first and second walls in said cavity.

2. A membrane unit as defined by claim 1, wherein said adsorbent is enveloped by or embedded in a porous membrane.

3. A membrane unit as defined in claim 2, wherein the pore size of said porous membrane is larger than the pore size of said permselective membrane.

4. A membrane unit as defined by claim 1, wherein said permselective membrane is applied to a fluid-absorbing and/or fluid-draining carrier.

5. A membrane unit as defined by claim 4, wherein said carrier is an adsorbent material comprising a porous artificial sponge composed of regenerated cellulose.

6. A membrane unit as defined by claim 1, wherein said permselective membrane is applied to a carrier containing a rinsing solution.

7. A membrane unit as defined by claim 1, wherein the surface of the adsorbent facing away from the permselective membrane forms at least one other cavity through which the contaminatd blood passes, said cavity being formed by the surface of the adsorbent facing away from the permselective membrane and an additional permselective membrane.

8. A membrane unit as defined by claim 1, wherein said adsorbent comprises a pyrolized and activated sheet-like textile.

9. A membrane unit as defined by claim 8, wherein said textile is composed of fibers selected from the group consisting of polyamide, polyester, polyacrylonitrile and cellulose containing fibers.

10. A membrane unit as defined by claim 8, wherein said textile comprises activated carbon.

11. A membrane unit as defined by claim 1, wherein said adsorbent has an ion exchange capacity.

12. A membrane unit as defined by claim 1, wherein said adsorbent is selected from the group consisting of hydrophobic synthetic material and porous synthetic resin.

13. A membrane unit as defined by claim 1, wherein said adsorbent is a sheet-like body having a profiled surface.

14. A membrane unit as defined by claim 13, wherein the permselective membrane is applied to a fluid-absorbing and/or fluid-draining carrier and is folded to form an accordian structure wherein said adsorbent is disposed between adjacent layers of said structure.

15. A membrane unit as defined by claim 13, wherein said adsorbent is folded to form an accordian structure wherein the permselective membrane is applied to a fluid-absorbing carrier which is disposed between adjacent layers of said structure.

16. A membrane unit as defined by claim 1, wherein the permselective membrane comprises a hollow capillary structure in which the adsorbent is located in the hollow interior space of the capillary, whereby said cavity is defined between the adsorbent and the interior walls of said capillary structure.

17. A membrane unit as defined by claim 1, wherein said unit is spirally rolled.

18. An apparatus for purifying blood, comprising said membrane unit as defined by claim 1 and connected thereto at least one inlet means for admitting contaminated blood and at least one outlet means for releasing the decontaminated blood.

19. An apparatus as defined by claim 18, wherein said membrane unit is spirally rolled.

20. An apparatus as defined by claim 18, wherein said membrane unit is folded to form an accordian structure.

21. An apparatus as defined by claim 18, wherein said membrane unit contains absorbent carriers which retain and collect and/or drain the filtrate from said membrane unit.

22. An apparatus as defined by claim 21, wherein said absorbent carriers are artificial sponge composed of regenerated cellulose.

23. An apparatus as defined by claim 18, containing a plurality of membrane units arranged side by side to form alternating layers of permselective membranes, cavities and adsorbents.

24. An apparatus as defined by claim 23, wherein said membrane units are capillary membrane units wherein the permselective membrane comprises a hollow capillary structure in which the adsorbent is located in the hollow interior space of the capillary, whereby said cavity is defined between the adsorbent and the interior walls of said capillary structure.

25. A membrane unit as defined by claim 1, wherein a spacer is disposed between the at least one permselective membrane and the at least one adsorbent to form the required cavity.

26. A membrane unit as defined by claim 25, wherein the permselective membrane and adsorbent surfaces are approximately parallel.

27. A membrane unit as defined by claim 1, wherein the pore size of said permselective membrane is between about 2 and 10 nm.

28. A method as defined by claim 1, wherein said adsorbent is granulated or powdery and is applied to the surface of a sheet-like body to define said second wall.

29. A method for simultaneously removing toxic metabolites and metabolites normally present in urine from blood, comprising the step of simultaneously directly contacting the blood with at least one permselective membrane having a pore size adapted to selectively remove from the blood metabolites normally present in urine, including water, electrolytes, urea and ammonia, and at least one adsorbent for removing toxic metabolites from the blood.

30. A method as defined by claim 29, wherein said adsorbent is enveloped by or embedded in a porous membrane having a pore size larger than the pore size of said permselective membrane.

31. A method as defined by claim 29, wherein said permselective membrane is applied to a fluid-absorbing and/or fluid-draining carrier.

32. A method as defined by claim 31, wherein said carrier is an absorbent material comprising a porous artificial sponge composed of regenerated cellulose.

33. A method as defined by claim 29, wherein said adsorbent is a sheet-like body having a profiled surface.