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Dual circuit, woven artificial capillary bundle for cell culture

  • US 4,184,922 A
  • Filed: 11/11/1977
  • Issued: 01/22/1980
  • Est. Priority Date: 11/11/1977
  • Status: Expired due to Term
First Claim
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1. A cell culture unit for the formation and maintenance of solid tissues and cells in vitro, comprising:

  • (a) shell means having spaced end portions and defining an elongated chamber therebetween;

    (b) an endpiece attached to each end of said shell means, each endpiece terminating at its outer end in a plurality of tubular header members;

    (c) capillary means within said chamber, said capillary means including a plurality of individual capillaries having walls which are permeable to nutrients required for cell growth or maintenance and/or cell products and being arranged with individual capillaries extending in a predetermined reproducible interwoven relationship with respect to each other, said capillaries dividing the chamber by the walls of the capillaries into an intracapillary space within the capillaries and an extracapillary space outside the capillaries, the intracapillary space and the extracapillary space communicating with each other only through the walls of the capillaries, a first portion of said capillaries extending through a first header at each end of the shell means and a second portion of said capillaries extending through a second header at each end of the shell means, each portion being woven with the other such that capillaries from the separate portions are in intimate contact in a regular pattern;

    (d) means communicating with the intracapillary space of said first portion of said capillaries for passing perfusate therethrough;

    (e) means communicating with the intracapillary space of said second portion of said capillaries for passing perfusate therethrough; and

    (f) means communicating with said extracapillary space for seeding cells and/or retrieving cells or cell products therefrom.

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