Isatin products

• US 4,186,132 A
• Filed: 04/15/1977
• Issued: 01/29/1980
• Est. Priority Date: 04/15/1977
• Status: Expired due to Term

• Current Assignee: Regents of The University of Minnesota (University of Minnesota)
• Original Assignee: Regents of The University of Minnesota (University of Minnesota)
• Inventors: Gassman, Paul G., Cue, Berkeley W.
• Primary Examiner(s): Rizzo, Nicholas S.
• Application Number:
  US05/787,992
• Time in Patent Office: 1,019 Days
• Field of Search: 260/325 R
• US Class Current: 548/485
• CPC Class Codes: C07D 209/30 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
• CPC Class Codes: C07D 209/34 in position 2
• CPC Class Codes: C07D 209/36 in position 3, e.g. adrenochrome
• CPC Class Codes: C07D 209/38 in positions 2 and 3, e.g. isatin
• CPC Class Codes: C09B 7/00 Indigoid dyes

Abstract

An aniline is converted to a 3-lower hydrocarbonthiooxindole by processes already known in the art, the product converted to a 3-halo-3-lower hydrocarbonthiooxindole by oxidative halogenation, and the product subjected to hydrolysis to form the desired isatins.

Claims

1. A compound of the formula ##STR12##

2. The compound of claim 1, 5-cyanoisatin.

3. A compound of the formula ##STR13## wherein R² is lower alkyl.

4. The compound of claim 3, in which R² is ethyl.

5. The compound of claim 4, 5-carbethoxyisatin.