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Method and apparatus for continuous plasmaphersis

  • US 4,191,182 A
  • Filed: 09/23/1977
  • Issued: 03/04/1980
  • Est. Priority Date: 09/23/1977
  • Status: Expired
First Claim
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1. An apparatus for the continuous separation of blood into a cellular component fraction and a plasma fraction comprising:

  • (a) an ultrafiltration cell comprising a filter membrane having a pore size of from about 0.1 to about 1.0 microns in diameter, said membrane separating said cell into filtering and filtrate chambers, said filtering chamber comprising an inlet and an outlet, and said filtrate chamber comprising an inlet and an outlet;

    (b) a blood input pumping means for pumping blood directly from a blood vessel to the inlet of said filtering chamber and delivering a flow of whole blood parallel to said filter membrane in depths of from about 0.1 mm to about 1.0 mm measured perpendicularly from the face of said membrane, and at rates sufficient to obtain a shear rate at the membrane interface of from about 10 dynes/cm2 to about 1000 dynes/cm2 ;

    (c) a pumping means to direct a portion of said plasma fraction flowing from the outlet of said filtrate chamber in a flow from the inlet to the outlet of said filtrate chamber and parallel and in the same direction as the flow of whole blood passing through said filtering chamber.

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